Effects of diet and of dietary components on endothelial leukocyte adhesion molecules

Endothelial-leukocyte adhesion molecules are involved in processes regulating the selective attachment of leukocytes to the vessel wall, which participate in tissue inflammation, atherogenesis, and immunity. There has been recent appreciation that diet or specific dietary components may modulate such processes. Highly unsaturated— particularly omega-3 — fatty acids and antioxidants are receiving increasing attention in this regard as potential antiatherogenic and anti-inflammatory agents. The vascular surface expression of endothelial leukocyte molecules can also be reflected by plasma levels of “soluble” adhesion molecules, thus allowing the assessment of the effects of diet and selected dietary components on these processes in vivo. © 1999, Current Science Inc.