Regulation of gene expression in the nervous system by reactive oxygen and nitrogen species

被引：0

作者：

Jean E. Merrill

Sean P. Murphy

机构：

[1] University of Iowa College of Medicine,Department of Pharmacology

[2] Berlex Biosciences,Department of Immunology

来源：

Metabolic Brain Disease | 1997年 / 12卷 / 2期

关键词：

CNS genes; cytokines; oxygen radicals; nitric oxide; transcription factors; neuropathologies;

D O I：

10.1007/BF02674732

中图分类号：

学科分类号：

摘要：

Reactive oxygen and nitrogen species function as direct and indirect modulators of gene expression through their interactions with transcription factors and also key enzymes in receptor-activated signalling pathways. This regulatory role may become displaced under certain circumstances such as aging, autoimmune responses and viral infection, leading to the pathological outcome associated with inflammatory and degenerative diseases in the CNS.

引用

页码：97 / 112

页数：15

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