Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy

被引:0
|
作者
Joshua C. Chang
Steffen Durinck
Mark Z. Chen
Nadia Martinez-Martin
Jingli A. Zhang
Isabelle Lehoux
Hong Li
May Lin
Jiansheng Wu
Travis W. Bainbridge
James A. Ernst
Sree R. Ramani
Sairupa Paduchuri
Lance Kates
Margaret Solon
Matthew B. Buechler
Alessandra Castiglioni
Minh Thai
Beatrice Breart
Zora Modrusan
Andrew S. Peterson
Shannon J. Turley
Junichiro Sonoda
机构
[1] Genentech,
[2] Inc.,undefined
[3] Regeneron Pharmaceuticals,undefined
[4] Inc.,undefined
来源
Scientific Reports | / 9卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
In response to environmental and nutrient stress, adipose tissues must establish a new homeostatic state. Here we show that cold exposure of obese mice triggers an adaptive tissue remodeling in visceral adipose tissue (VAT) that involves extracellular matrix deposition, angiogenesis, sympathetic innervation, and adipose tissue browning. Obese VAT is predominated by pro-inflammatory M1 macrophages; cold exposure induces an M1-to-M2 shift in macrophage composition and dramatic changes in macrophage gene expression in both M1 and M2 macrophages. Antibody-mediated CSF1R blocking prevented the cold-induced recruitment of adipose tissue M2 macrophages, suggesting the role of CSF1R signaling in the process. These cold-induced effects in obese VAT are phenocopied by an administration of the FGF21-mimetic antibody, consistent with its action to stimulate sympathetic nerves. Collectively, these studies illuminate adaptive visceral adipose tissue plasticity in obese mice in response to cold stress and antibody-based metabolic therapy.
引用
收藏
相关论文
共 34 条
  • [21] Mimicking polyclonal immune response in therapy: from combination of two monoclonal antibodies to oligoclonal antibody-based mixtures
    Larbouret, Christel
    Poul, Marie-Alix
    Chardes, Thierry
    M S-MEDECINE SCIENCES, 2020, 35 (12): : 1083 - 1091
  • [22] Response of Adipose Tissue-Derived Stromal Cells in Tissue-Related O2 Microenvironment to Short-Term Hypoxic Stress
    Andreeva, Elena R.
    Lobanova, Margarita V.
    Udartseva, Olga O.
    Buravkova, Ludmila B.
    CELLS TISSUES ORGANS, 2014, 200 (05) : 307 - 315
  • [23] Endothelial Differentiation of Adipose Tissue-Derived Mesenchymal Stromal Cells in Glioma Tumors: Implications for Cell-Based Therapy
    Bago, Juli R.
    Alieva, Maria
    Soler, Carolina
    Rubio, Nuria
    Blanco, Jeronimo
    MOLECULAR THERAPY, 2013, 21 (09) : 1758 - 1766
  • [24] Attenuation of cold stress-induced exacerbation of cardiac and adipose tissue pathology and metabolic disorders in a rat model of metabolic syndrome by the glucocorticoid receptor antagonist RU486
    K Nagasawa
    N Matsuura
    Y Takeshita
    S Ito
    Y Sano
    Y Yamada
    A Uchinaka
    T Murohara
    K Nagata
    Nutrition & Diabetes, 2016, 6 : e207 - e207
  • [25] Attenuation of cold stress-induced exacerbation of cardiac and adipose tissue pathology and metabolic disorders in a rat model of metabolic syndrome by the glucocorticoid receptor antagonist RU486
    Nagasawa, K.
    Matsuura, N.
    Takeshita, Y.
    Ito, S.
    Sano, Y.
    Yamada, Y.
    Uchinaka, A.
    Murohara, T.
    Nagata, K.
    NUTRITION & DIABETES, 2016, 6 : e207 - e207
  • [26] The Glucocorticoid Receptor Antagonist RU486 Ameliorates Cold Stress-induced Exacerbation of Cardiac and Adipose Tissue Pathology and Metabolic Disorders in a Rat Model of Metabolic Syndrome
    Nagasawa, Kai
    Matsuura, Natsumi
    Minagawa, Yuji
    Ito, Shogo
    Sano, Yusuke
    Hattori, Takuya
    Yamada, Yuichiro
    Watanabe, Shogo
    Murohara, Toyoaki
    Nagata, Kohzo
    HYPERTENSION, 2014, 64
  • [27] Gene Therapy Based on Mesenchymal Stem Cells Derived from Adipose Tissue for the Treatment of Obesity and Its Metabolic Complications
    Lopez-Yus, Marta
    Garcia-Sobreviela, Maria Pilar
    del Moral-Bergos, Raquel
    Arbones-Mainar, Jose M.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (08)
  • [28] iTRAQ-based quantitative proteome revealed metabolic changes of Flammulina velutipes mycelia in response to cold stress
    Liu, Jing-Yu
    Men, Jun-long
    Chang, Ming-chang
    Feng, Cui-ping
    Yuan, Ling-Gang
    JOURNAL OF PROTEOMICS, 2017, 156 : 75 - 84
  • [29] Macrophage Response to Allogeneic Adipose Tissue-Derived Stromal Cells in Hyaluronan-Based Hydrogel in a Porcine Vocal Fold Injury Model
    King, Suzanne N.
    Woo, Joo Hyun
    Tang, Sharon
    Thibeault, Susan L.
    ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2017, 126 (06): : 463 - 477
  • [30] Comparable in vitro Function of Human Liver-Derived and Adipose Tissue-Derived Mesenchymal Stromal Cells: Implications for Cell-Based Therapy
    Yigitbilek, Furkan
    Conley, Sabena M.
    Tang, Hui
    Saadiq, Ishran M.
    Jordan, Kyra L.
    Lerman, Lilach O.
    Taner, Timucin
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9