Establishment and improvement of model of vascularized heart-thymus composite transplantation in rats

被引：0
|
作者：
Hai-bo Xiong
Sui-sheng Xia
Hao Wen
Zu-fa Huang
Qi-fa Ye
机构：
[1] Central South University,Medical Academy of Transplantation, the Third Xiangya Hospital
[2] Huazhong Science and Technological University,Institute of Transplantation, Tongji Hospital
[3] Xinjiang Medical University,Department of General Surgery, the First Affiliated Hospital
来源：
Journal of Central South University of Technology | 2005年 / 12卷
关键词：
heart; thymus; composite transplantation; rat; animal model; transplantation immunity; R392.4;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective To establish and improve the model of heart-thymus composite transplantation. Methods Vascularized both lobes of the thymus is transplanted heterotopically with the heart as a composite graft in rats. This technique was developed and assessed, and viability of the grafts was evaluated histologically. Results Donor operation costed 38.5 ± 3.52 min, vascular anastomosis costed 25.0 ± 3.28 min, operating successful rate was 90%, acute rejection was observed in SD-Wistar group, viable thymus with normal microarchitecture was maintained in Wistar-Wistar group. Conclusions The improved novel technique for combined heart-thymus transplantation is a valuable method for study of the role of thymus in transplantation immunity.
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页码：347 / 349
页数：2
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