Cytochemical Evaluation of the Toxic Effects of Combined Antituberculosis Substances on Metabolic State of Blood Lymphocytes

被引：0
|
作者：
M. V. Dolgushin
机构：
[1] V. F. Voino-Yasenetsky Krasnoyarsk State Medical University,Department of Human Anatomy and Histology
[2] Ministry of Health of the Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2020年 / 168卷
关键词：
lymphocytes; dehydrogenases; hydrolases; antituberculosis substances; toxic effects;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Combined antituberculosis substances induced a dose-dependent changes in activity of dehydrogenases and hydrolases in rat lymphocytes. The main toxic effect of the substances was related to inhibition of mitochondrial dehydrogenases (succinate dehydrogenase and α-glycerol phosphate dehydrogenase) usually followed by suppression of activity of hydrolytic enzymes (acid phosphatase and non-specific esterase). Opposite changes in lactate dehydrogenase activity reflected specific features of intoxication.
引用
收藏
页码：470 / 473
页数：3
相关论文
共 50 条
  • [41] IMMUNOMODULATION IN-VITRO - EFFECTS OF THYMIC SUBSTANCES THYMEX-L AND TFX-THYMOMODULIN ON PERIPHERAL-BLOOD LYMPHOCYTES OF LUNG-CANCER PATIENTS
    VUCKOVICDEKIC, L
    STANOJEVICBAKIC, N
    RAJNER, L
    RADOSAVLJEVIC, D
    DEKIC, M
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 1995, 14 (01) : 51 - 57
  • [42] EVALUATION OF MONOOXYGENASES ACTIVATING CARCINOGENS AND MUTAGENIC EFFECTS OF BENZO(A) PYRENE WHEN STUDYING BLOOD-LYMPHOCYTES IN WORKERS OF ALUMINUM MAKING INDUSTRY
    KESOVA, IG
    SEDOVA, KS
    TSYRLOV, IB
    EKSPERIMENTALNAYA ONKOLOGIYA, 1991, 13 (03): : 12 - 15
  • [43] The Effects of a 12-Week Combined Exercise Training Program on Arterial Stiffness, Vasoactive Substances, Inflammatory Markers, Metabolic Profile, and Body Composition in Obese Adolescent Girls
    Wong, Alexei
    Sanchez-Gonzalez, Marcos A.
    Son, Won-Mok
    Kwak, Yi-Sub
    Park, Song-Young
    PEDIATRIC EXERCISE SCIENCE, 2018, 30 (04) : 480 - 486
  • [44] Influence of algal-extracellular polymeric substances (EPS) on the pristine and combined toxicity of TiO2 NPs and PSNPs in Artemia salina: Eco-corona enhances the toxic effects
    Natarajan, Lokeshwari
    Jenifer, M. Annie
    Mukherjee, Amitava
    ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2024, 282
  • [45] Effects of combined exposure to modeled radiation and gravitation factors of the interplanetary flight: Monkeys' cognitive functions and the content of monoamines and their metabolites; cytogenetic changes in peripheral blood lymphocytes
    Belyaeva, Alexandra G.
    Kudrin, Vladimir S.
    Koshlan, Igor, V
    Koshlan, Nataliya A.
    Isakova, Mariya D.
    Bogdanova, Yulia, V
    Timoshenko, Gennady N.
    Krasavin, Evgeny A.
    Blokhina, Taisia M.
    Yashkina, Elizaveta I.
    Osipov, Andreyan N.
    Nosovsky, Andrey N.
    Perevezentsev, Alexandr A.
    Shtemberg, Andrey S.
    LIFE SCIENCES IN SPACE RESEARCH, 2021, 30 : 45 - 54
  • [46] Evaluation of a protocol for metabolic profiling studies on human blood plasma by combined ultra-performance liquid chromatography/mass spectrometry: From extraction to data analysis
    Bruce, Stephen J.
    Jonsson, Par
    Antti, Henrik
    Cloarec, Olivier
    Trygg, Johan
    Marklund, Stefan L.
    Moritz, Thomas
    ANALYTICAL BIOCHEMISTRY, 2008, 372 (02) : 237 - 249
  • [47] Cationized hyperimmune immunoglobulins: Pharmacokinetics, toxicity evaluation and treatment of human immunodeficiency virus-infected human-peripheral blood lymphocytes-severe combined immune deficiency mice
    Pardridge, WM
    Kang, YS
    Diagne, A
    Zack, JA
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1996, 276 (01): : 246 - 252
  • [48] EVALUATION OF HUMAN BLOOD-LYMPHOCYTES AS A MODEL TO STUDY THE EFFECTS OF DRUGS ON HUMAN MITOCHONDRIA - EFFECTS OF LOW CONCENTRATIONS OF AMIODARONE ON FATTY-ACID OXIDATION, ATP LEVELS AND CELL-SURVIVAL
    FROMENTY, B
    LETTERON, P
    FISCH, C
    BERSON, A
    DESCHAMPS, D
    PESSAYRE, D
    BIOCHEMICAL PHARMACOLOGY, 1993, 46 (03) : 421 - 432
  • [49] The effects of a 12-week combined exercise training program on arterial stiffness, vasoactive substances, inflammatory markers, metabolic profile, and body composition in obese adolescent girls (vol 30, pg 480, 2018)
    Wong, A.
    Sanchez-Gonzalez, M. A.
    Son, W-M
    Kwak, Y-S
    Park, S-Y
    PEDIATRIC EXERCISE SCIENCE, 2020, 32 (03) : 183 - 183
  • [50] IMMUNOLOGICAL EVALUATION OF LONG-TERM EFFECTS OF CHILDHOOD ALL CHEMOTHERAPY - ANALYSIS OF INVITRO NK-CELL AND K-CELL ACTIVITIES OF PERIPHERAL-BLOOD LYMPHOCYTES
    MCGEORGE, MB
    RUSSELL, EC
    MOHANAKUMAR, T
    AMERICAN JOURNAL OF HEMATOLOGY, 1982, 12 (01) : 19 - 27
12345