Cytochemical Evaluation of the Toxic Effects of Combined Antituberculosis Substances on Metabolic State of Blood Lymphocytes

被引：0
|
作者：
M. V. Dolgushin
机构：
[1] V. F. Voino-Yasenetsky Krasnoyarsk State Medical University,Department of Human Anatomy and Histology
[2] Ministry of Health of the Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2020年 / 168卷
关键词：
lymphocytes; dehydrogenases; hydrolases; antituberculosis substances; toxic effects;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Combined antituberculosis substances induced a dose-dependent changes in activity of dehydrogenases and hydrolases in rat lymphocytes. The main toxic effect of the substances was related to inhibition of mitochondrial dehydrogenases (succinate dehydrogenase and α-glycerol phosphate dehydrogenase) usually followed by suppression of activity of hydrolytic enzymes (acid phosphatase and non-specific esterase). Opposite changes in lactate dehydrogenase activity reflected specific features of intoxication.
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页码：470 / 473
页数：3
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