Kicking off sphingolipid biosynthesis: structures of the serine palmitoyltransferase complex

被引:0
|
作者
Binks W. Wattenberg
机构
[1] Virginia Commonwealth University School of Medicine,Department of Biochemistry and Molecular Biology
来源
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Structures of the human serine palmitoyltransferase complex reveal the overall assembly, regulatory mechanisms and substrate selectivity of this key enzyme in sphingolipid synthesis.
引用
收藏
页码:229 / 231
页数:2
相关论文
共 50 条
  • [21] Sphingolipid synthesis: Identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase
    Nagiec, MM
    Lester, RL
    Dickson, RC
    GENE, 1996, 177 (1-2) : 237 - 241
  • [22] Induction of sphingolipid production in cultured human keratinocytes by LXR activators through increased expression of serine palmitoyltransferase
    Douangpanya, S
    Uchida, Y
    Mills, K
    Casiday, JA
    Trejo, A
    Elias, PM
    Holleran, WM
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 122 (03) : A76 - A76
  • [23] Orosomucoid Proteins Interact with the Small Subunit of Serine Palmitoyltransferase and Contribute to Sphingolipid Homeostasis and Stress Responses in Arabidopsis
    Li, Jian
    Yin, Jian
    Rong, Chan
    Li, Kai-En
    Wu, Jian-Xin
    Huang, Li-Qun
    Zeng, Hong-Yun
    Sahu, Sunil Kumar
    Yao, Nan
    PLANT CELL, 2016, 28 (12): : 3038 - 3051
  • [24] Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells - A novel evaluation system using an SPT-defective mammalian cell mutant
    Hanada, K
    Nishijima, M
    Fujita, T
    Kobayashi, S
    BIOCHEMICAL PHARMACOLOGY, 2000, 59 (10) : 1211 - 1216
  • [25] SPHINGOLIPID LONG-CHAIN BASE SYNTHESIS IN PLANTS - CHARACTERIZATION OF SERINE PALMITOYLTRANSFERASE ACTIVITY IN SQUASH FRUIT MICROSOMES
    LYNCH, DV
    FAIRFIELD, SR
    PLANT PHYSIOLOGY, 1993, 103 (04) : 1421 - 1429
  • [26] Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways
    Bugajev, Viktor
    Paulenda, Tomas
    Utekal, Pavol
    Mrkacek, Michal
    Halova, Ivana
    Kuchar, Ladislav
    Kuda, Ondrej
    Vavrova, Petra
    Schuster, Bjorn
    Fuentes-Liso, Sergio
    Potuckova, Lucie
    Smrz, Daniel
    Cernohouzova, Sara
    Draberova, Lubica
    Bambouskova, Monika
    Draber, Petr
    JOURNAL OF LIPID RESEARCH, 2021, 62
  • [27] Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis
    Kuo, Andrew
    Checa, Antonio
    Niaudet, Colin
    Jung, Bongnam
    Fu, Zhongjie
    Wheelock, Craig E.
    Singh, Sasha A.
    Aikawa, Masanori
    Smith, Lois E.
    Proia, Richard L.
    Hla, Timothy
    ELIFE, 2022, 11
  • [28] Activity of partially inhibited serine palmitoyltransferase is sufficient for normal sphingolipid metabolism and viability of HSN1 patient cells
    Dedov, VN
    Dedova, IV
    Merrill, AH
    Nicholson, GA
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2004, 1688 (02): : 168 - 175
  • [29] Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis
    Bejaoui, K
    Uchida, Y
    Yasuda, S
    Ho, M
    Nishijima, M
    Brown, RH
    Holleran, WM
    Hanada, K
    JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (09): : 1301 - 1308
  • [30] Myriocin, a serine palmitoyltransferase inhibitor, suppresses tumor growth in a murine melanoma model by inhibiting de novo sphingolipid synthesis
    Lee, Youn-Sun
    Choi, Kyeong-Mi
    Lee, Seunghyun
    Sin, Dong-Mi
    Yoo, Kwang-Sik
    Lim, Yong
    Lee, Yong-Moon
    Hong, Jin-Tae
    Yun, Yeo-Pyo
    Yoo, Hwan-Soo
    CANCER BIOLOGY & THERAPY, 2012, 13 (02) : 92 - 100