Structural basis for retroviral integration into nucleosomes

被引：0

作者：

Daniel P. Maskell

Ludovic Renault

Erik Serrao

Paul Lesbats

Rishi Matadeen

Stephen Hare

Dirk Lindemann

Alan N. Engelman

Alessandro Costa

Peter Cherepanov

机构：

[1] Chromatin Structure and Mobile DNA,Department of Cancer Immunology and AIDS

[2] The Francis Crick Institute,Division of Medicine

[3] Architecture and Dynamics of Macromolecular Machines,undefined

[4] Clare Hall Laboratories,undefined

[5] The Francis Crick Institute,undefined

[6] National Institute for Biological Standards and Control,undefined

[7] Microscopy and Imaging,undefined

[8] Dana-Farber Cancer Institute,undefined

[9] NeCEN,undefined

[10] Gorlaeus Laboratory,undefined

[11] Imperial College London,undefined

[12] Institute of Virology,undefined

[13] Technische Universität Dresden,undefined

[14] †Present address: Division of Molecular Biosciences,undefined

[15] Imperial College London,undefined

[16] South Kensington Campus,undefined

[17] London SW7 2AZ,undefined

[18] UK,undefined

来源：

Nature | 2015年 / 523卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Retroviruses such as HIV rely on the intasome, a tetramer of integrase protein bound to the viral DNA ends interacting with host chromatin, for integration into the host genome; the structure of the intasome as it interacts with a nucleosome is now solved, giving insight into the integration process.

引用

页码：366 / 369

页数：3

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