Nitrogen Oxide, Endothelin-1, and Serotonin in the Blood of Immature Spontaneously Hypertensive Rats

被引：0
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作者：
M. D. Chibireva
G. N. Aflyatumova
V. L. Matveeva
D. F. Bilalova
O. I. Kuz’mina
D. I. Sadykova
R. R. Nigmatullina
机构：
[1] Kazan State Medical University,
[2] Ministry of Health of the Russian Federation,undefined
[3] Kazan State Medical Academy,undefined
[4] Ministry of Health of the Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2017年 / 162卷
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摘要：
Endothelial function is an early and sensitive marker of subclinical increase of BP in children and adolescents. It is associated with an imbalance of the key vasoactive factors (NO, endothelin-1, and serotonin). Immature spontaneously hypertensive rats (SHR line) are characterized by increased plasma concentrations of NO and endothelin-1 (by 14.7% and 2.9 times, respectively) and increased serotonin content in the plasma and platelets (by 2.7 and 2.3 times, respectively) in comparison with Wistar-Kyoto rats. Platelet count in the blood of SHR rats is by 50% higher than in Wistar-Kyoto rats.
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页码：310 / 312
页数：2
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