S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life

被引：0
|
作者：
Jin Gao
Catherine M. Cahill
Xudong Huang
Joshua L. Roffman
Stefania Lamon-Fava
Maurizio Fava
David Mischoulon
Jack T. Rogers
机构：
[1] Massachusetts General Hospital and Harvard Medical School,Department of Psychiatry
[2] Massachusetts General Hospital and Harvard Medical School,Neurochemistry Laboratory, Department of Psychiatry
[3] Qilu Hospital of Shandong University,Department of Clinical Psychology
[4] Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University,undefined
来源：
Neurotherapeutics | 2018年 / 15卷
关键词：
S-Adenosyl-methionine; Transmethylation; Pathway; Psychiatric disease; Neurodegenerative disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
S-Adenosyl methionine (SAMe), as a major methyl donor, exerts its influence on central nervous system function through cellular transmethylation pathways, including the methylation of DNA, histones, protein phosphatase 2A, and several catecholamine moieties. Based on available evidence, this review focuses on the lifelong range of severe neuropsychiatric and neurodegenerative diseases and their associated neuropathologies, which have been linked to the deficiency/load of SAMe production or/and the disturbance in transmethylation pathways. Also included in this review are the present-day applications of SAMe in the treatment in these diseases in each age group.
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页码：156 / 175
页数：19
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