S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life

被引：0
|
作者：
Jin Gao
Catherine M. Cahill
Xudong Huang
Joshua L. Roffman
Stefania Lamon-Fava
Maurizio Fava
David Mischoulon
Jack T. Rogers
机构：
[1] Massachusetts General Hospital and Harvard Medical School,Department of Psychiatry
[2] Massachusetts General Hospital and Harvard Medical School,Neurochemistry Laboratory, Department of Psychiatry
[3] Qilu Hospital of Shandong University,Department of Clinical Psychology
[4] Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University,undefined
来源：
Neurotherapeutics | 2018年 / 15卷
关键词：
S-Adenosyl-methionine; Transmethylation; Pathway; Psychiatric disease; Neurodegenerative disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
S-Adenosyl methionine (SAMe), as a major methyl donor, exerts its influence on central nervous system function through cellular transmethylation pathways, including the methylation of DNA, histones, protein phosphatase 2A, and several catecholamine moieties. Based on available evidence, this review focuses on the lifelong range of severe neuropsychiatric and neurodegenerative diseases and their associated neuropathologies, which have been linked to the deficiency/load of SAMe production or/and the disturbance in transmethylation pathways. Also included in this review are the present-day applications of SAMe in the treatment in these diseases in each age group.
引用
收藏
页码：156 / 175
页数：19
相关论文
共 50 条
  • [1] S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life
    Gao, Jin
    Cahill, Catherine M.
    Huang, Xudong
    Roffman, Joshua L.
    Lamon-Fava, Stefania
    Fava, Maurizio
    Mischoulon, David
    Rogers, Jack T.
    NEUROTHERAPEUTICS, 2018, 15 (01) : 156 - 175
  • [2] S-adenosyl L-methionine in CNS diseases
    Krzystanek, Marek
    Palasz, Artur
    Krzystanek, Ewa
    Krupka-Matuszczyk, Irena
    Wiaderkiewicz, Ryszard
    Skowronek, Rafal
    PSYCHIATRIA POLSKA, 2011, 45 (06) : 923 - 931
  • [3] NEUROPHARMACOLOGY OF S-ADENOSYL METHIONINE
    CARNEY, MWP
    CLINICAL NEUROPHARMACOLOGY, 1986, 9 (03) : 235 - 243
  • [4] INHIBITION OF S-ADENOSYL METHIONINE DECARBOXYLASE BY GUANETHIDINE
    JOHNSON, EM
    TAYLOR, AS
    BIOCHEMICAL PHARMACOLOGY, 1980, 29 (01) : 113 - 115
  • [5] S-Adenosyl Methionine (SAMe) for Depression in Adults
    Wilson, Amanda
    ISSUES IN MENTAL HEALTH NURSING, 2019, 40 (08) : 725 - 726
  • [6] S-adenosyl methionine (SAMe) for depression in adults
    Galizia, Ilaria
    Oldani, Lucio
    Macritchie, Karine
    Amari, Erica
    Dougall, Dominic
    Jones, Tessa N.
    Lam, Raymond W.
    Massei, Guido Jacopo
    Yatham, Lakshmi N.
    Young, Allan H.
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2016, (10):
  • [7] CYANIDE INTOXICATION AND THE EFFECT OF S-ADENOSYL METHIONINE
    BUZALEH, AM
    VAZQUEZ, E
    WIDER, E
    BATLLE, AM
    ARCHIVOS DE BIOLOGIA Y MEDICINA EXPERIMENTALES, 1986, 19 (02): : R186 - R186
  • [8] EFFECT OF KETONE BODIES AND ACTH ON TRANSMETHYLATION REACTION (S-ADENOSYL METHIONINE INDEPENDENT SYSTEM) IN RATS .I.
    NATH, MC
    NATH, N
    ENZYMOLOGIA, 1969, 36 (02) : 79 - &
  • [9] Homocysteine and lipids: S-Adenosyl methionine as a key intermediate
    Obeid, Rima
    Herrmann, Wolfgang
    FEBS LETTERS, 2009, 583 (08) : 1215 - 1225
  • [10] Computational Study of the Degradation of S-Adenosyl Methionine in Water
    Lankau, Timm
    Kuo, Tzu Nung
    Yu, Chin Hui
    JOURNAL OF PHYSICAL CHEMISTRY A, 2017, 121 (02): : 505 - 514
12345