Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

被引：0

作者：

Jochen Huehn

Julia K. Polansky

Alf Hamann

机构：

[1] Helmholtz Centre for Infection Research,Jochen Huehn and Julia K. Polansky are at the Department of Experimental Immunology

[2] Braunschweig,Alf Hamann is at the Department of Experimental Rheumatology

[3] Germany.,undefined

[4] Charité University Medicine,undefined

[5] Berlin,undefined

[6] Germany.,undefined

来源：

Nature Reviews Immunology | 2009年 / 9卷

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学科分类号：

摘要：

Regulatory T (TReg) cells are crucial for immune homeostasis, and manipulation of their suppressive functions is a possible avenue for immunotherapy. Here, the authors discuss recent advances in our understanding of how the expression of forkhead box P3 (FOXP3), a TReg-cell-specifying transcription factor, is controlled at the molecular level.

引用

页码：83 / 89

页数：6

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