Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

被引：0
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作者：
Jochen Huehn
Julia K. Polansky
Alf Hamann
机构：
[1] Helmholtz Centre for Infection Research,Jochen Huehn and Julia K. Polansky are at the Department of Experimental Immunology
[2] Braunschweig,Alf Hamann is at the Department of Experimental Rheumatology
[3] Germany.,undefined
[4] Charité University Medicine,undefined
[5] Berlin,undefined
[6] Germany.,undefined
来源：
Nature Reviews Immunology | 2009年 / 9卷
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摘要：
Regulatory T (TReg) cells are crucial for immune homeostasis, and manipulation of their suppressive functions is a possible avenue for immunotherapy. Here, the authors discuss recent advances in our understanding of how the expression of forkhead box P3 (FOXP3), a TReg-cell-specifying transcription factor, is controlled at the molecular level.
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页码：83 / 89
页数：6
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