Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding

被引：0
|
作者：
Mayumi Ito
Zaixin Yang
Thomas Andl
Chunhua Cui
Noori Kim
Sarah E. Millar
George Cotsarelis
机构：
[1] Kligman Laboratories,Department of Dermatology
[2] University of Pennsylvania School of Medicine,undefined
[3] Philadelphia,undefined
[4] Pennsylvania 19104,undefined
[5] USA,undefined
来源：
Nature | 2007年 / 447卷
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摘要：
The mammalian hair follicle is thought to form anew only during development, and loss of an adult follicle is generally considered permanent. Fifty years ago in Nature, Billingham and Russel reported 'hair neogenesis' in rabbit skin, but this was later discounted. Now it is back, with the discovery that hair follicle regeneration is triggered by wounding the skin of adult mice. This suggests that mammalian skin responds to wounding with greater plasticity and regenerative capacity than was previously believed, and has implications for those studying wound healing, tissue regeneration and stem cell function.
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页码：316 / 320
页数：4
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