Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding

被引：0
|
作者：
Mayumi Ito
Zaixin Yang
Thomas Andl
Chunhua Cui
Noori Kim
Sarah E. Millar
George Cotsarelis
机构：
[1] Kligman Laboratories,Department of Dermatology
[2] University of Pennsylvania School of Medicine,undefined
[3] Philadelphia,undefined
[4] Pennsylvania 19104,undefined
[5] USA,undefined
来源：
Nature | 2007年 / 447卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The mammalian hair follicle is thought to form anew only during development, and loss of an adult follicle is generally considered permanent. Fifty years ago in Nature, Billingham and Russel reported 'hair neogenesis' in rabbit skin, but this was later discounted. Now it is back, with the discovery that hair follicle regeneration is triggered by wounding the skin of adult mice. This suggests that mammalian skin responds to wounding with greater plasticity and regenerative capacity than was previously believed, and has implications for those studying wound healing, tissue regeneration and stem cell function.
引用
收藏
页码：316 / 320
页数：4
相关论文
共 42 条
  • [1] Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
    Ito, Mayumi
    Yang, Zaixin
    Andl, Thomas
    Cui, Chunhua
    Kim, Noori
    Millar, Sarah E.
    Cotsarelis, George
    NATURE, 2007, 447 (7142) : 316 - U4
  • [2] Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding
    Wier, Eric M.
    Garza, Luis A.
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2020, 100 : 122 - 129
  • [3] Epigenetic control of skin and hair regeneration after wounding
    Plikus, Maksim V.
    Guerrero-Juarez, Christian Fernando
    Treffeisen, Elsa
    Gay, Denise L.
    EXPERIMENTAL DERMATOLOGY, 2015, 24 (03) : 167 - 170
  • [4] Epidermal Wnt ligands are required for adult hair follicle regeneration
    Myung, P.
    Takeo, M.
    Ito, M.
    Atit, R.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2012, 132 : S138 - S138
  • [5] Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration
    Myung, Peggy S.
    Takeo, Makoto
    Ito, Mayumi
    Atit, Radhika P.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2013, 133 (01) : 31 - 41
  • [6] Induction of hair follicle neogenesis with cultured mouse dermal papilla cells in de novo regenerated skin tissues
    Zhang, Long
    Wang, Wen-Hui
    Jin, Jane Y.
    Degan, Simone
    Zhang, Guo-Qiang
    Erdmann, Detlev
    Hall, Russell P.
    Zhang, Jennifer Y.
    JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2019, 13 (09) : 1641 - 1650
  • [7] De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated β-catenin in skin
    Gat, U
    DasGupta, R
    Degenstein, L
    Fuchs, E
    CELL, 1998, 95 (05) : 605 - 614
  • [8] Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors
    Wang, Xiaoxiao
    Wang, Xusheng
    Liu, Jianjun
    Cai, Ting
    Guo, Ling
    Wang, Shujuan
    Wang, Jinmei
    Cao, Yanpei
    Ge, Jianfeng
    Jiang, Yuyang
    Tredget, Edward E.
    Cao, Mengjun
    Wu, Yaojiong
    STEM CELLS TRANSLATIONAL MEDICINE, 2016, 5 (12) : 1695 - 1706
  • [9] Hair follicle-induced de novo adipogenesis in adult cutaneous wounds
    Plikus, M.
    Ito, M.
    Dedhia, P.
    Gay, D.
    Shetova, O.
    Millar, S.
    Lazar, M.
    Cotsarelis, G.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2012, 132 : S143 - S143
  • [10] Diphtheria Toxin-Induced Cell Death Triggers Wnt-Dependent Hair Cell Regeneration in Neonatal Mice
    Hu, Lingxiang
    Lu, Jingrong
    Chiang, Hao
    Wu, Hao
    Edge, Albert S. B.
    Shi, Fuxin
    JOURNAL OF NEUROSCIENCE, 2016, 36 (36): : 9479 - 9489
12345