Simultaneous voltammetric detection of 5-hydroxyindole-3-acetic acid and 5-hydroxytryptamine using a glassy carbon electrode modified with conducting polymer and platinised carbon nanofibers

被引：0
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作者：
Zina Fredj
MounirBen Ali
Baljit Singh
Eithne Dempsey
机构：
[1] University of Sousse,Higher Institute of Applied Sciences and Technology of Sousse, GREENS
[2] NANOMISENE Lab,ISSAT
[3] LR16CRMN01,MiCRA Biodiagnostics, Centre of Applied Science for Health
[4] Centre for Research on Microelectronics and Nanotechnology of Sousse,Department of Chemistry
[5] Technopole of Sousse,undefined
[6] Institute of Technology Tallaght,undefined
[7] Maynooth University,undefined
来源：
Microchimica Acta | 2018年 / 185卷
关键词：
5-Hydroxyindole-3-acetic acid; 5-Hydroxytryptamine; Pt nanocomposites; Pyrrole-3-carboxylic acid; Stripping square wave voltammetry; Quantitation in artificial urine;
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摘要：
The authors describe a method for simultaneous voltammetric determination of 5-hydroxytryptamine (serotonin; 5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). A glassy carbon electrode was modified with poly(pyrrole-3-carboxylic acid) and with platinised carbon nanofibers to obtain a sensor that can quantify 5-HT and 5-HIAA with detection limits of 10 nM and 20 nM, respectively. The peak currents, best measured at voltages of 170 mV and 500 mV (vs. Ag/AgCl) for 5-HT and 5-HIAA, increase linearly in the 0.01–100 μM concentration range for both analytes. The method was successfully applied to the quantitation of 5-HT and 5-HIAA in spiked artificial urine samples, and the sensor can be used up to 10 days.
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