Treatment with 7-Nitroindazole Enhances Kainic Acid Induced Cholinergic Neurotoxicity in the Rat Striatum: A Neuroprotective Role for Neuronal Nitric Oxide

被引：0
|
作者：
Beatriz H. Guevara
Ghislaine C. Cespedes
Luigi X. Cubeddu
机构：
[1] Central University of Venezuela,Neuropharmacology Unit, Department of Pharmacology, School of Pharmacy
[2] Central University of Venezuela,Neuropathology Unit, Institute of Pathology, School of Medicine
[3] Nova Southeastern University,HPD
来源：
Cellular and Molecular Neurobiology | 2002年 / 22卷
关键词：
brain nitric oxide; kainic acid; 7-nitroindazole; striatum; neurotoxicity; cholinergic neurons;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
1. In this study we investigated the effect of 7-nitroindazole (7-NI), a preferential inhibitor of neuronal nitric oxide synthase (nNOS), on kainic acid (KA) induced neurotoxicity in rats. Choline acetyltransferase activity (CAT), a cholinergic marker, and histological changes were employed to assess neurotoxicity.
引用
收藏
页码：827 / 834
页数：7
相关论文
共 50 条
  • [21] The Effect of Neuronal Nitric Oxide Synthase Inhibitor 7-Nitroindazole on the Cell Death Induced by Zinc Administration in the Brain of Rats
    Gokce, M. Fatih
    Bagirici, Faruk
    Demir, Serif
    Bostanci, M. Omer
    Guven, Aysel
    TURKISH JOURNAL OF MEDICAL SCIENCES, 2009, 39 (02) : 197 - 202
  • [22] Neuroprotective effects of melatonin and methylisothiourea 0N cholinergic damage induced by kainic acid in the rat striatum
    Guevara, BH
    Campos, M
    Cespedes, G
    Cubeddu, LX
    JOURNAL OF NEUROCHEMISTRY, 2001, 78 : 189 - 189
  • [23] Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model
    Enkhbaatar, P
    Murakami, K
    Shimoda, K
    Mizutani, A
    McGuire, R
    Schmalstieg, F
    Cox, R
    Hawkins, H
    Jodoin, J
    Lee, S
    Traber, L
    Herndon, D
    Traber, D
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2003, 285 (02) : R366 - R372
  • [24] Relatively selective neuronal nitric oxide synthase inhibition by 7-nitroindazole in monkey isolated cerebral arteries
    Ayajiki, K
    Fujioka, H
    Okamura, T
    Toda, N
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 423 (2-3) : 179 - 183
  • [25] 7-nitroindazole reduces nitric oxide concentration in rat hippocampus after transient forebrain ischemia
    Jiang, MH
    Kaku, T
    Hada, J
    Hayashi, Y
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 380 (2-3) : 117 - 121
  • [26] 7-Nitroindazole, nNOS inhibitor, attenuates amphetamine-induced amino acid release and nitric oxide generation but not lipid peroxidation in the rat brain
    Bashkatova, V
    Kraus, MM
    Vanin, A
    Hornick, A
    Philippu, A
    Prast, H
    JOURNAL OF NEURAL TRANSMISSION, 2005, 112 (06) : 779 - 788
  • [27] 7-Nitroindazole, nNOS inhibitor, attenuates amphetamine-induced amino acid release and nitric oxide generation but not lipid peroxidation in the rat brain
    V. Bashkatova
    M. M. Kraus
    A. Vanin
    A. Hornick
    A. Philippu
    H. Prast
    Journal of Neural Transmission, 2005, 112 : 779 - 788
  • [28] The role of 7-nitroindazole in prolonged seizures induced by kainic acid in young rats, submitted to hypoxia during the perinatal period.
    Papadopoulou, I
    Karkavelas, G
    Spandou, E
    Simeonidou, C
    Liangouris, I
    Grigoriadis, N
    Guiba-Tziampiri, O
    PEDIATRIC RESEARCH, 2005, 58 (02) : 402 - 402
  • [29] 7-NITROINDAZOLE EFFECTS ON L-DOPA-INDUCED DYSKINESIAS AND ON STRIATAL NITRIC OXIDE PRODUCTION
    Padovan-Neto, F. E.
    Romano, A. C.
    Ferreira, F.
    Del Bel, E. A.
    JOURNAL OF NEUROCHEMISTRY, 2009, 110 : 47 - 47
  • [30] In vitro and in vivo evidences that antioxidant action contributes to the neuroprotective effects of the neuronal nitric oxide synthase and monoamine oxidase-B inhibitor, 7-nitroindazole
    Thomas, Bobby
    Saravanan, Karuppagounder S.
    Mohanakumar, Kochupurackal P.
    NEUROCHEMISTRY INTERNATIONAL, 2008, 52 (06) : 990 - 1001
12345