Treatment with 7-Nitroindazole Enhances Kainic Acid Induced Cholinergic Neurotoxicity in the Rat Striatum: A Neuroprotective Role for Neuronal Nitric Oxide

被引：0
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作者：
Beatriz H. Guevara
Ghislaine C. Cespedes
Luigi X. Cubeddu
机构：
[1] Central University of Venezuela,Neuropharmacology Unit, Department of Pharmacology, School of Pharmacy
[2] Central University of Venezuela,Neuropathology Unit, Institute of Pathology, School of Medicine
[3] Nova Southeastern University,HPD
来源：
Cellular and Molecular Neurobiology | 2002年 / 22卷
关键词：
brain nitric oxide; kainic acid; 7-nitroindazole; striatum; neurotoxicity; cholinergic neurons;
D O I：
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学科分类号：
摘要：
1. In this study we investigated the effect of 7-nitroindazole (7-NI), a preferential inhibitor of neuronal nitric oxide synthase (nNOS), on kainic acid (KA) induced neurotoxicity in rats. Choline acetyltransferase activity (CAT), a cholinergic marker, and histological changes were employed to assess neurotoxicity.
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页码：827 / 834
页数：7
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