Sex differences in the human metabolome

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作者
Michele Costanzo
Marianna Caterino
Giovanni Sotgiu
Margherita Ruoppolo
Flavia Franconi
Ilaria Campesi
机构
[1] University of Naples Federico II,Department of Molecular Medicine and Medical Biotechnology, School of Medicine
[2] CEINGE – Biotecnologie Avanzate s.c.ar.l.,Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Sciences
[3] University of Sassari,Laboratory of Sex
[4] National Institute of Biostructures and Biosystems,Gender Medicine
[5] University of Sassari,Department of Biomedical Sciences
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关键词
Metabolomics; Sex differences; Age; Metabolic signature; Liquid biopsy; Biomarkers;
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摘要
Metabolomics is the gold-standard analytical approach to detect metabolic signatures in human biofluids.Analyzing the metabolome at the baseline in healthy individuals is important to identify metabolite signatures to be attributed to one sex or both.Differences in the metabolome of biofluids are sex- and age-dependent.Sex is not still adequately considered in metabolomics-based investigations.
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