FLIP-mediated autophagy regulation in cell death control

被引：0

作者：

Jong-Soo Lee

Qinglin Li

June-Yong Lee

Sun-Hwa Lee

Joseph H. Jeong

Hye-Ra Lee

Heesoon Chang

Fu-Chun Zhou

Shou-Jiang Gao

Chengyu Liang

Jae U. Jung

机构：

[1] University of Southern California,Department of Molecular Microbiology and Immunology

[2] Keck School of Medicine,Department of Microbiology and Molecular Genetics and Tumour Virology Division

[3] Harlyne J. Norris Cancer Research Tower,Department of Pediatrics

[4] New England Primate Research Center,Department of Cancer Immunology and AIDS, Dana

[5] Harvard Medical School,Farber Cancer Institute and the Department of Pathology

[6] The University of Texas Health Science Center at San Antonio,undefined

[7] Harvard Medical School,undefined

来源：

Nature Cell Biology | 2009年 / 11卷

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学科分类号：

摘要：

Two inhibitors of death receptor-associated apoptosis, cellular c-FLIP and viral v-FLIP prevents LC3 processing by Atg3 and thus repress the autophagic cell death that follows mTOR inhibition. Short peptides derived from FLIP can prevent Atg3–FLIP interaction without affecting Atg3–LC3, restoring cell death.

引用

页码：1355 / 1362

页数：7

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