Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension

被引：0
|
作者：
Andrzej Fedorowicz
Łukasz Mateuszuk
Grzegorz Kopec
Tomasz Skórka
Barbara Kutryb-Zając
Agnieszka Zakrzewska
Maria Walczak
Andrzej Jakubowski
Magdalena Łomnicka
Ewa Słomińska
Stefan Chlopicki
机构：
[1] Jagiellonian University,Jagiellonian Centre for Experimental Therapeutics (JCET)
[2] John Paul II Hospital in Krakow,Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College
[3] Institute of Nuclear Physics Polish Academy of Sciences,Chair and Department of Biochemistry, Faculty of Medicine
[4] Medical University of Gdańsk,Department of Toxicology
[5] Jagiellonian University Medical College,Chair of Pharmacology
[6] Jagiellonian University Medical College,undefined
来源：
Respiratory Research | / 17卷
关键词：
Pulmonary hypertension; Idiopathic pulmonary hypertension; Isolated lungs; Nicotinamide N-methyltransferase; Prostacyclin, Pulmonary endothelial dysfunction; Monocrotaline;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)
    Policarpo, Rocco L.
    Decultot, Ludovic
    May, Elizabeth
    Kuzmic, Petr
    Carlson, Samuel
    Huang, Danny
    Chu, Vincent
    Wright, Brandon A.
    Dhakshinamoorthy, Saravanakumar
    Kannt, Aimo
    Rani, Shilpa
    Dittakavi, Sreekanth
    Panarese, Joseph D.
    Gaudet, Rachelle
    Shair, Matthew D.
    JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (21) : 9837 - 9873
  • [22] Differential Expression of Nicotinamide N-methyltransferase (NNMT) in Stroma of Invasive Breast Cancer
    Roy, Madhuchhanda
    Esbona, Karla
    Lengyel, Ernst
    Eckert, Mark
    McGregor, Stephanie M.
    MODERN PATHOLOGY, 2018, 31 : 101 - 101
  • [23] Potent Uncompetitive Inhibitors of Nicotinamide N-Methyltransferase (NNMT) as In Vivo Chemical Probes
    Barrows, Robert D.
    Jeffries, Daniel E.
    Vishe, Mahesh
    Tukachinsky, Hanna
    Zheng, Shao-Liang
    Li, Fanfan
    Ma, Zhenjie
    Li, Xiaolei
    Jin, Shujuan
    Song, Haobin
    Zhang, Ruonan
    Zhang, Shaofeng
    Ni, Jing
    Luan, Haofei
    Wen, Lei
    Rongshan, Yan
    Ying, Chen
    Shair, Matthew D.
    JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (21) : 14642 - 14654
  • [24] Differential Expression of Nicotinamide N-methyltransferase (NNMT) in Stroma of Invasive Breast Cancer
    Roy, Madhuchhanda
    Esbona, Karla
    Lengyel, Ernst
    Eckert, Mark
    McGregor, Stephanie M.
    LABORATORY INVESTIGATION, 2018, 98 : 101 - 101
  • [25] Knockdown of Nicotinamide N-Methyltransferase (NNMT) Reverses Diet-Induced Obesity
    Kraus, Daniel
    Yang, Qin
    Pulinilkunnil, Thomas C.
    Rodgers, Joseph T.
    Monia, Brett P.
    Bhanot, Sanjay
    Becker, Thomas C.
    Peron, Odile D.
    Puigserver, Pere
    Kahn, Barbara B.
    DIABETES, 2010, 59 : A468 - A468
  • [26] Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide
    Swaminathan, Srinivasan
    Birudukota, Swarnakumari
    Thakur, Manish Kumar
    Parveen, Reejuana
    Kandan, Saravanan
    Juluri, Suresh
    Shaik, Shama
    Anand, Niranjan Naranapura
    Burri, Raghunadha Reddy
    Kristam, Rajendra
    Hallur, Mahanandeesha Siddappa
    Rajagopal, Sridharan
    Schreuder, Herman
    Langer, Thomas
    Rudolph, Christine
    Ruf, Sven
    Dhakshinamoorthy, Saravanakumar
    Gosu, Ramachandraiah
    Kannt, Aimo
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 491 (02) : 416 - 422
  • [27] NICOTINAMIDE N-METHYLTRANSFERASE (NNMT) AS A POTENTIAL THERAPEUTIC TARGET FOR EGFRVIII-DRIVEN GLIOBLASTOMA
    Li, Ming
    Chen, Clark
    NEURO-ONCOLOGY, 2023, 25
  • [28] High stromal nicotinamide N-methyltransferase (NNMT) indicates poor prognosis in colorectal cancer
    Song, Mengmeng
    Li, Ye
    Miao, Mingyong
    Zhang, Fan
    Yuan, Hao
    Cao, Fuao
    Chang, Wenjun
    Shi, Hanping
    Song, Chunhua
    CANCER MEDICINE, 2020, 9 (06): : 2030 - 2038
  • [29] 1-methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway
    Chlopicki, S.
    Swies, J.
    Mogielnicki, A.
    Buczko, W.
    Bartus, M.
    Lomnicka, M.
    Adamus, J.
    Gebicki, J.
    BRITISH JOURNAL OF PHARMACOLOGY, 2007, 152 (02) : 230 - 239
  • [30] Nicotinamide N-Methyltransferase (NNMT) Has Prognostic Implications for Microsatellite-Stable Colorectal Adenocarcinoma
    Ogawa, Makiko
    Tanaka, Atsushi
    Namba, Kei
    Klimstra, David
    Shia, Jinru
    Roehrl, Michael
    MODERN PATHOLOGY, 2021, 34 (SUPPL 2) : 458 - 459
12345