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- [30] The times have changed: molecular pathology is here to stayA commentary on: Analytical performance of a PCR assay for the detection of KRAS mutations (codons 12/13 and 61) in formalin-fixed paraffin-embedded tissue samples of colorectal carcinoma, by Lee et al. In this issue [J]. Virchows Archiv, 2012, 460 : 129 - 130