Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

被引：0

作者：

Andre Franke

Dermot P B McGovern

Jeffrey C Barrett

Kai Wang

Graham L Radford-Smith

Tariq Ahmad

Charlie W Lees

Tobias Balschun

James Lee

Rebecca Roberts

Carl A Anderson

Joshua C Bis

Suzanne Bumpstead

David Ellinghaus

Eleonora M Festen

Michel Georges

Todd Green

Talin Haritunians

Luke Jostins

Anna Latiano

Christopher G Mathew

Grant W Montgomery

Natalie J Prescott

Soumya Raychaudhuri

Jerome I Rotter

Philip Schumm

Yashoda Sharma

Lisa A Simms

Kent D Taylor

David Whiteman

Cisca Wijmenga

Robert N Baldassano

Murray Barclay

Theodore M Bayless

Stephan Brand

Carsten Büning

Albert Cohen

Jean-Frederick Colombel

Mario Cottone

Laura Stronati

Ted Denson

Martine De Vos

Renata D'Inca

Marla Dubinsky

Cathryn Edwards

Tim Florin

Denis Franchimont

Richard Gearry

Jürgen Glas

Andre Van Gossum

机构：

[1] Institute of Clinical Molecular Biology,Department of Medicine

[2] Christian-Albrechts-University Kiel,Department of Medicine

[3] Inflammatory Bowel and Immunobiology Research Institute,Department of Genetics

[4] Cedars-Sinai Medical Center,Department of Genetics

[5] Medical Genetics Institute,Department of Medical and Molecular Genetics

[6] Cedars-Sinai Medical Center,Department of Health Studies

[7] Wellcome Trust Sanger Institute,Department of Medicine

[8] Wellcome Trust Genome Campus,Department of Pediatrics

[9] Center for Applied Genomics,Department of Medicine

[10] The Children's Hospital of Philadelphia,Department of Medicine II

[11] Inflammatory Bowel Disease Research Group,Department of Gastroenterology

[12] Queensland Institute of Medical Research,Department of Biology of Radiations and Human Health

[13] Peninsula College of Medicine and Dentistry,Department of Hepatology and Gastroenterology

[14] Gastrointestinal Unit,Division of Gastroenterology

[15] Molecular Medicine Centre,Department of Pediatrics

[16] University of Edinburgh,Department of Gastroenterology

[17] Western General Hospital,Department of Gastroenterology

[18] PopGen Biobank,Department of Preventive Dentistry and Periodontology

[19] Christian-Albrechts University Kiel,Department of Human Genetics

[20] Inflammatory Bowel Disease Research Group,Department of Pediatrics

[21] Addenbrooke's Hospital,Department of Medicine

[22] University of Cambridge,Department of Gastroenterology

[23] University of Otago,Department of Gastroenterology

[24] Cardiovascular Health Research Unit,Division of Gastroenterology

[25] University of Washington,Department of Medicine

[26] University Medical Center Groningen,Department of Medical Genetics

[27] Faculty of Veterinary Medicine,Department of Gastroenterology

[28] University of Liège,Division of Gastroenterology

[29] Center for Human Genetic Research,Department of Paediatric Gastroenterology

[30] Massachusetts General Hospital,Division of Gastroenterology

[31] Harvard Medical School,Department of Gastroenterology

[32] Unit of Gastroenterology,Division of Gastroenterology

[33] Istituto di Ricovero e Cura a Carattere Scientifico-Casa Sollievo della Sofferenza (IRCCS-CSS) Hospital,Department of Gastroenterology

[34] King's College London School of Medicine,Department of Clinical Science Intervention and Technology

[35] Guy's Hospital,Division of Clinical Pharmacology and Toxicology

[36] Molecular Epidemiology,Department of Biosciences and Nutrition

[37] Queensland Institute of Medical Research,Department of Gastroenterology

[38] University of Chicago,Department of Pediatrics

[39] Section of Digestive Diseases,Department of Human Genetics

[40] Yale University,Department for General Internal Medicine

[41] Center for Pediatric Inflammatory Bowel Disease,Department of Genetics

[42] The Children's Hospital of Philadelphia,undefined

[43] Inflammatory Bowel Disease Center,undefined

[44] Johns Hopkins University School of Medicine,undefined

[45] University Hospital Munich Grosshadern,undefined

[46] Ludwig-Maximilians-University,undefined

[47] Charité,undefined

[48] Campus Mitte,undefined

[49] Universitätsmedizin Berlin,undefined

[50] Montreal Jewish General Hospital,undefined

来源：

Nature Genetics | 2010年 / 42卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Miles Parkes and colleagues report results of a large genome-wide association meta-analysis and replication study for Crohn's disease. They identify 30 new susceptibility loci for this inflammatory bowel disease and implicate several interesting candidate genes in disease pathogenesis.

引用

页码：1118 / 1125

页数：7

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