The protective effect of Myrtus communis L. against experimental kidney stone in rats

被引：0
|
作者：
Halil Yılmaz
Nihat Ekinci
Ayşe Ömerli
Mehtap Nisari
Arzu Hanım Yay
Harun Ülger
Gökçe Şeker Karatoprak
Seher Yımaz
Şükrü Ateş
Mustafa Taştan
机构：
[1] Nevsehir Haci Bektas Veli University,Department of Therapy and Rehabilitation, Kozakli Vocational School
[2] Erciyes University,Department of Anatomy, Faculty of Medicine
[3] Nuh Naci Yazgan University,Department of Anatomy, Faculty of Dentsitry
[4] Erciyes University,Department of Histology Embryology, Faculty of Medicine
[5] Erciyes University,Department of Pharmacognosy, Faculty of Pharmacy
[6] Bozok University,Department of Anatomy, Faculty of Medicine
[7] Lokman Hekim University,Department of Anatomy, Faculty of Medicine
来源：
Advances in Traditional Medicine | 2023年 / 23卷
关键词：
Calcium oxalate; Ethylene glicole; Pizzolato's; Staining; Urine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aim of this study is to investigate the protective effect of 70% methanolic extract of Myrtus communis L. leaves (300 mg/kg) against the kidney stone modeling created by (0.75%) ethylene glycole. Twenty-eight, 10 week’s Sprague Dawley male rats were divided into four groups (n = 7) as the control group, ethylene glycol (EG) group, M. communis (MC) group and protective (EG + MC) group. For 28 days, while 0.75% EG was given by adding it to drinking water to occur kidney stone model, MC was given by gavage to test the protective effect. 24 h’ urine samples were taken, and calcium, creatinine, uric acid, magnesium, citrate and oxalate were evaluated. On the 28th day, the rats were sacrificed, and their kidneys were removed. Kidney tissues were examined with hematoxylin eosin (HE) staining and kidney stones formed with Pizzolato’s (PZ) staining technique were shown. M. communis extract brought abnormal urine parameter values closer to the control group. Additionally, it was concluded that the tissue degeneration and number of stones decreased in the protective group. M. communis extract has a protective effect against the kidney stone modeling which created by EG.
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页码：241 / 249
页数：8
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