Characterizations of coal fly ash nanoparticles and induced in vitro toxicity in cell lines

被引：0
|
作者：
Bharathi Sambandam
Eganathan Palanisami
Rajasekar Abbugounder
Balakrishnamurthy Prakhya
Devasena Thiyagarajan
机构：
[1] Anna University,Centre for Nanoscience and Technology
[2] M. S. Swaminathan Research Foundation,Plant Tissue Culture and Bioprospecting Laboratory
[3] International Institute for Biotechnology and Toxicology (IIBAT),undefined
来源：
Journal of Nanoparticle Research | 2014年 / 16卷
关键词：
Coal fly ash; Coal fly ash nanoparticles; MTT assay; Cytotoxicity; Environmental and health effects;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The present study illustrates the characterization and cytotoxicity studies of coal fly ash nanoparticles (CFA-NPs). The coal fly ash (CFA) collected from electrostatic precipitator of a coal-fired power plant and the average size of the CFA-NPs was found to be 9–50 nm. Imaging techniques showed predominantly homogenous spherical shaped nanoparticles. The X-ray diffraction analysis and energy dispersive X-ray (EDAX) analysis spectra reveal the elemental constituents of the CFA-NPs contain several toxic heavy metals. Cytotoxicity of CFA-NPs was determined by MTT assay. Cellular metabolism is inhibited in a dose dependent manner by CFA concentrations varying from 13 to 800 μg mL−1. After 48 h exposure, the Hep2, A549 and HepG2 cell lines prove more sensitive to CFA-NPs at varying levels which results in IC50 (50 % inhibitory concentration) cytotoxicity end point.
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