Antiviral Activity of Technologically Processed Antibodies to CD4 Receptor against Influenza Infection

被引：0
|
作者：
N. V. Petrova
A. G. Emelyanova
S. A. Tarasov
Е. А. Glubokova
N. P. Каrtashova
机构：
[1] Research Institute of General Pathology and Pathophysiology,
[2] I. I. Mechnikov Research Institute of Vaccines and Sera,undefined
[3] LLC “MATERIA MEDICA HOLDING”,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2022年 / 174卷
关键词：
influenza А infection; technologically processed antibodies; CD4 receptor; Ergoferon; Raphamin;
D O I：
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中图分类号：
学科分类号：
摘要：
The antiviral activity of technologically processed antibodies to CD4 receptor was evaluated a model of sublethal A/California/04/2009 (H1N1)pdm09-induced influenza infection in female BALB/c mice. The technologically processed antibodies increased animal survival rate by 50% in comparison with the placebo group (p<0.05), which correlated with significant inhibition of virus replication in the lungs (p<0.05). The reference drug Tamiflu increased mouse survival rate (by 47%), decreased the virus titer in the lungs, and prevented body weight loss (p<0.05 in comparison with the placebo group by all parameters). The intrinsic protective activity of technologically processed antibodies to CD4 receptor was demonstrated, which manifested in a decrease in viral load in the lower respiratory tract and an increase in the survival rate.
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页码：250 / 253
页数：3
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