Random Laser Emission Spectra of the Normal and Cancerous Thyroid Tissues

In this work, the random laser is investigated as a diagnostic method to distinguish between normal and cancerous Rd6G-infiltrated in vitro human thyroid tissues. The inherent disorder of the tissues provides the necessary condition for the formation of a number of microresonators providing field feedback for lasing. The longer light path random walk inside a scattering media leads to the stronger reabsorption events. Accordingly, a notable redshift of the LIF emission is observed in the random laser spectra of the cancerous tissues against normal ones. The Fourier transform and power Fourier transform of random laser spectra collected from many excitation locations in the tissue give rise to the rapid identification of normal and malignant tissues. Moreover, the mean sizes of the randomly formed microresonators are estimated to be ~ 20 μm, comparable to the average size of the typical thyroid cell.