How do you design randomised trials for smaller populations? A framework

被引：0
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作者：
Mahesh K. B. Parmar
Matthew R. Sydes
Tim P. Morris
机构：
[1] Aviation House,London Hub for Trials Methodology Research, MRC Clinical Trials Unit at UCL
[2] London School of Hygiene and Tropical Medicine,Medical Statistics Dept.
来源：
BMC Medicine | / 14卷
关键词：
Randomised trials; Trial design; Smaller populations; Uncommon diseases;
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摘要：
How should we approach trial design when we can get some, but not all, of the way to the numbers required for a randomised phase III trial?
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