Synthesis of 5-azolyl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and 5-azolyl-1,3,4-thiadiazol-2-amines based on derivatives of 5-arylisoxazole-3-carboxylic and 4,5-dichloroisothiazole-3-carboxylic acids

被引：0

作者：

Sergey K. Petkevich

Neliya А. Zhukovskaya

Evgenij А. Dikusar

Ekaterina А. Akishina

Peter V. Kurman

Eugeniya V. Nikitina

Vladimir P. Zaytsev

Vladimir I. Potkin

机构：

[1] Institute of Physical Organic Chemistry,

[2] National Academy of Sciences of Belarus,undefined

[3] Institute of Bioorganic Chemistry,undefined

[4] National Academy of Sciences of Belarus,undefined

[5] RUDN University,undefined

来源：

Chemistry of Heterocyclic Compounds | 2021年 / 57卷

关键词：

isothiazole; isoxazole; thiadiazoles; thiosemicarbazides; triazoles; heterocyclization;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

2-Mercapto-1,3,4-triazoles and 2-amino-1,3,4-thiadiazoles were synthesized by successive transformations of 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carboxylic acids and their derivatives. The amino group of 5-(4,5-dichloroisothiazol-3-yl)-1,3,4-thiadiazol-2-amine was acylated with 5-phenylisoxazole-3-carboxylic acid chloride. Simple approaches to the preparation of previously unknown heterocyclic assemblies containing two or three azole rings with a high potential for biological activity are described.

引用

页码：594 / 598

页数：4

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