Synthesis of 5-azolyl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and 5-azolyl-1,3,4-thiadiazol-2-amines based on derivatives of 5-arylisoxazole-3-carboxylic and 4,5-dichloroisothiazole-3-carboxylic acids

被引：0
|
作者：
Sergey K. Petkevich
Neliya А. Zhukovskaya
Evgenij А. Dikusar
Ekaterina А. Akishina
Peter V. Kurman
Eugeniya V. Nikitina
Vladimir P. Zaytsev
Vladimir I. Potkin
机构：
[1] Institute of Physical Organic Chemistry,
[2] National Academy of Sciences of Belarus,undefined
[3] Institute of Bioorganic Chemistry,undefined
[4] National Academy of Sciences of Belarus,undefined
[5] RUDN University,undefined
来源：
Chemistry of Heterocyclic Compounds | 2021年 / 57卷
关键词：
isothiazole; isoxazole; thiadiazoles; thiosemicarbazides; triazoles; heterocyclization;
D O I：
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中图分类号：
学科分类号：
摘要：
2-Mercapto-1,3,4-triazoles and 2-amino-1,3,4-thiadiazoles were synthesized by successive transformations of 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carboxylic acids and their derivatives. The amino group of 5-(4,5-dichloroisothiazol-3-yl)-1,3,4-thiadiazol-2-amine was acylated with 5-phenylisoxazole-3-carboxylic acid chloride. Simple approaches to the preparation of previously unknown heterocyclic assemblies containing two or three azole rings with a high potential for biological activity are described.
引用
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页码：594 / 598
页数：4
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