A redundant oncogenic potential of the retinoic receptor (RAR) α, β and γ isoforms in acute promyelocytic leukemia

被引：0
|
作者：
A Marinelli
D Bossi
P G Pelicci
S Minucci
机构：
[1] University of Milan,Department of Biomolecular Sciences and Biotechnology
[2] European Institute of Oncology,Department of Experimental Oncology
来源：
Leukemia | 2007年 / 21卷
关键词：
acute myeloid leukemias; acute promyelocytic leukemia; PML-RAR; retinoic acid;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Alterations of the retinoic acid receptor (RAR)α locus are found in 100% of acute promyelocytic leukemia patients, where chromosomal translocations generate the promyelocytic leukemia (PML)-RARα chimeric protein. Here, we have investigated the biological properties of the other RAR isoforms (RARβ and RARγ), through the generation and characterization of artificial PML-RAR‘x’ fusion proteins. Surprisingly, we found that all of the RAR isoforms share an identical oncogenic potential in vitro, thus implying that the selection of the RARα locus in leukemia patients must occur – rather than through functional differences among the various RAR isoforms–as the consequence of the nuclear architecture of the different RAR loci.
引用
收藏
页码：647 / 650
页数：3
相关论文
共 50 条
  • [31] Acute Myeloid Leukemia Acquiring Promyelocytic Leukemia-Retinoic Acid Receptor Alpha at Relapse
    Gupta, Varsha
    Shariff, Mohammed
    Bajwa, Ravneet
    Patel, Ishan
    Ayyad, Hashem A.
    Levitt, Michael J.
    Mencel, Peter J.
    Hossain, Mohammad A.
    WORLD JOURNAL OF ONCOLOGY, 2019, 10 (03) : 153 - 156
  • [32] Successful all-trans retinoic acid treatment of acute promyelocytic leukemia in a patient with NPM/RAR fusion
    Okazuka K.
    Masuko M.
    Seki Y.
    Hama H.
    Honma N.
    Furukawa T.
    Toba K.
    Kishi K.
    Aizawa Y.
    International Journal of Hematology, 2007, 86 (3) : 246 - 249
  • [33] Relapse of acute promyelocytic leukemia (APL) is associated with increased methylation of the retinoic acid receptor-beta2 (RARβ2) gene promoter
    Zhou, DC
    Kim, H
    Tallman, MS
    Gallagher, RE
    BLOOD, 2004, 104 (11) : 318A - 319A
  • [34] Expression patterns of specific promyelocytic/retinoic acid receptor-α transcripts in patients with acute promyelocytic leukemia
    Lin, J.
    Han, L. -X.
    Qian, J.
    Wang, Y. -L.
    Yao, D. -M.
    Qian, Z.
    Yang, X. -F.
    Sheng, X. -J.
    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2010, 32 (03) : 344 - 350
  • [35] Expression of retinoic acid receptor–target genes during retinoic acid therapy for acute promyelocytic leukemia
    K Takitani
    M Koh
    C L Zhu
    A Inoue
    T Kuno
    H Tanoue
    M Miyake
    T Nakagawa
    H Tamai
    Leukemia, 2003, 17 : 646 - 648
  • [36] Acute promyelocytic leukemia:: PML/RARα and the leukemic stem cell
    Puccetti, E
    Ruthardt, M
    LEUKEMIA, 2004, 18 (07) : 1169 - 1175
  • [37] Acute promyelocytic leukemia: PML/RARα and the leukemic stem cell
    E Puccetti
    M Ruthardt
    Leukemia, 2004, 18 : 1169 - 1175
  • [38] Role of RARα-PLZF in the pathogenesis of acute promyelocytic leukemia.
    He, LZ
    Ivins, S
    Zelent, A
    Pandolfi, PP
    BLOOD, 1998, 92 (10) : 480A - 480A
  • [39] Acute promyelocytic leukemia:: Mechanisms of PML-RARα action
    Reineke, EL
    Liu, H
    Liu, Y
    Kao, HY
    FASEB JOURNAL, 2006, 20 (05): : A966 - A966
  • [40] Acute promyelocytic leukemia with a PLZF-RARα fusion protein
    Jansen, JH
    Löwenberg, B
    SEMINARS IN HEMATOLOGY, 2001, 38 (01) : 37 - 41
12345