A redundant oncogenic potential of the retinoic receptor (RAR) α, β and γ isoforms in acute promyelocytic leukemia

被引：0
|
作者：
A Marinelli
D Bossi
P G Pelicci
S Minucci
机构：
[1] University of Milan,Department of Biomolecular Sciences and Biotechnology
[2] European Institute of Oncology,Department of Experimental Oncology
来源：
Leukemia | 2007年 / 21卷
关键词：
acute myeloid leukemias; acute promyelocytic leukemia; PML-RAR; retinoic acid;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Alterations of the retinoic acid receptor (RAR)α locus are found in 100% of acute promyelocytic leukemia patients, where chromosomal translocations generate the promyelocytic leukemia (PML)-RARα chimeric protein. Here, we have investigated the biological properties of the other RAR isoforms (RARβ and RARγ), through the generation and characterization of artificial PML-RAR‘x’ fusion proteins. Surprisingly, we found that all of the RAR isoforms share an identical oncogenic potential in vitro, thus implying that the selection of the RARα locus in leukemia patients must occur – rather than through functional differences among the various RAR isoforms–as the consequence of the nuclear architecture of the different RAR loci.
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页码：647 / 650
页数：3
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