Level of blood cell-free circulating mitochondrial DNA as a novel biomarker of acute myocardial ischemia

被引：0

作者：

N. P. Sudakov

T. P. Popkova

A. I. Katyshev

O. A. Goldberg

S. B. Nikiforov

B. G. Pushkarev

I. V. Klimenkov

S. A. Lepekhova

K. A. Apartsin

G. A. Nevinsky

Yu. M. Konstantinov

机构：

[1] Irkutsk Surgery and Traumatology Research Center,Irkutsk Research Center

[2] Irkutsk State University,Siberian Institute of Plant Physiology and Biochemistry

[3] Siberian Branch of the Russian Academy of Sciences,Limnological Institute

[4] Siberian Branch of the Russian Academy of Sciences,Institute of Chemical Biology and Fundamental Medicine

[5] Siberian Branch of the Russian Academy of Sciences,undefined

[6] Siberian Branch of the Russian Academy of Sciences,undefined

来源：

Biochemistry (Moscow) | 2015年 / 80卷

关键词：

acute ischemic myocardial injury; cell-free circulating mtDNA; cytolysis biomarkers; real-time PCR;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Changes in the level of blood cell-free circulating mitochondrial DNA were examined during experimental adrenaline-induced myocardial injury in rats. The amount of mitochondrial DNA in the blood was significantly elevated at 48 and 72 h after subcutaneous injection of adrenaline solution, and it was accompanied by development of multiple smallfocal myocardial ischemia. This suggests that the measured level of blood cell-free circulating mitochondrial DNA might be used as a biomarker of acute myocardial ischemia.

引用

页码：1387 / 1392

页数：5

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