ATP-dependent chromatin remodelers and aging

During aging, cells are continuously exposed to a range of environmental and endogenous conditions causing DNA damage, genomic instability and cellular stresses. At the DNA damage sites, essential biological processes such as transcription and replication are impeded, which can cause diseases of premature aging and cancer. Chromatin structure limits access to DNA, which serves as a docking site for DNA repair, signaling proteins and transcription factors. There is growing body of evidence that suggests that chromatin structure is involved in regulating aging. Accordingly, the activity of ATP-dependent chromatin remodeling complexes is gradually gaining interest in this process. Despite ATP-dependent chromatin remodelers being extensively studied, their role in aging and lifespan regulation remains less studied. This review focuses mainly on discussing the role of ATP-dependent chromatin remodelers in genome stability, induction of stress response pathways and regulation of aging.