Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment

被引：0
|
作者：
Dar Meshi
Michael R Drew
Michael Saxe
Mark S Ansorge
Denis David
Luca Santarelli
Chariklia Malapani
Holly Moore
René Hen
机构：
[1] Columbia University,Department of Biological Sciences
[2] Center for Neurobiology and Behavior,Department of Psychiatry
[3] Columbia University,undefined
[4] Biopsychology Unit,undefined
[5] New York State Psychiatric Institute,undefined
[6] Columbia University,undefined
[7] Faculté de Pharmacie,undefined
[8] Université Paris-Sud,undefined
[9] Tour D1,undefined
[10] 2e etage,undefined
[11] EA3544,undefined
来源：
Nature Neuroscience | 2006年 / 9卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment.
引用
收藏
页码：729 / 731
页数：2
相关论文
共 50 条
  • [21] ENVIRONMENTAL ENRICHMENT SELECTIVELY INCREASES ROSTRAL HIPPOCAMPAL NEUROGENESIS AFTER MWM TRAINING IN TBI RATS
    Lajud Avila, Naima
    Rojo-Soto, Georgina
    Bondi, Corina
    Cheng, Jeffrey
    Kline, Anthony
    [J]. JOURNAL OF NEUROTRAUMA, 2016, 33 (13) : A122 - A122
  • [22] Environmental exploration, individuality, and hippocampal neurogenesis
    不详
    [J]. NEUROSCIENTIST, 2013, 19 (05): : 431 - 431
  • [23] Environmental and pharmacological regulation of hippocampal neurogenesis
    Sackeim, HA
    Manji, HK
    Perera, TD
    Santarelli, L
    Kornack, D
    Kempermann, G
    Eisch, A
    [J]. BIOLOGICAL PSYCHIATRY, 2003, 53 (08) : 3S - 3S
  • [24] BEHAVIORAL EFFECTS OF ENVIRONMENTAL ENRICHMENT IN RANDOMLY BRED MICE
    MANOSEVITZ, M
    JOEL, U
    [J]. JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1973, 85 (02) : 373 - 382
  • [25] EFFECTS OF ENVIRONMENTAL ENRICHMENT ON BEHAVIORAL DEFICITS AND ALTERATIONS IN HIPPOCAMPAL BDNF INDUCED BY PRENATAL EXPOSURE TO MORPHINE IN JUVENILE RATS
    Ahmadalipour, A.
    Sadeghzadeh, J.
    Vafaei, A. A.
    Bandegi, A. R.
    Mohammadkhani, R.
    Rashidy-Pour, A.
    [J]. NEUROSCIENCE, 2015, 305 : 372 - 383
  • [26] Environmental enrichment: Effects on spatial memory and hippocampal CREB immunoreactivity
    Williams, BM
    Luo, Y
    Ward, C
    Redd, K
    Gibson, R
    Kuczaj, SA
    McCoy, JG
    [J]. PHYSIOLOGY & BEHAVIOR, 2001, 73 (04) : 649 - 658
  • [27] Environmental enrichment effects on synaptic and cellular physiology of hippocampal neurons
    Ohline, S. M.
    Abraham, W. C.
    [J]. NEUROPHARMACOLOGY, 2019, 145 : 3 - 12
  • [28] Environmental Enrichment and Physical Exercise Revert Behavioral and Electrophysiological Impairments Caused by Reduced Adult Neurogenesis
    Sakalem, Marna Eliana
    Seidenbecher, Thomas
    Zhang, Mingyue
    Saffari, Roja
    Kravchenko, Mykola
    Woerdemann, Stephanie
    Diederich, Kai
    Schwamborn, Jens C.
    Zhang, Weiqi
    Ambree, Oliver
    [J]. HIPPOCAMPUS, 2017, 27 (01) : 36 - 51
  • [29] Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment
    Kempermann, G
    Gast, D
    Gage, FH
    [J]. ANNALS OF NEUROLOGY, 2002, 52 (02) : 135 - 143
  • [30] Environmental enrichment alleviates cognitive and psychomotor alterations and increases adult hippocampal neurogenesis in cocaine withdrawn mice
    Carmen Manas-Padilla, M.
    Tezanos, Patricia
    Cintado, Elisa
    Vicente, Lucia
    Sanchez-Salido, Lourdes
    Gil-Rodriguez, Sara
    Trejo, Jose L.
    Santin, Luis J.
    Castilla-Ortega, Estela
    [J]. ADDICTION BIOLOGY, 2023, 28 (01)
12345