Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment

被引：0

作者：

Dar Meshi

Michael R Drew

Michael Saxe

Mark S Ansorge

Denis David

Luca Santarelli

Chariklia Malapani

Holly Moore

René Hen

机构：

[1] Columbia University,Department of Biological Sciences

[2] Center for Neurobiology and Behavior,Department of Psychiatry

[3] Columbia University,undefined

[4] Biopsychology Unit,undefined

[5] New York State Psychiatric Institute,undefined

[6] Columbia University,undefined

[7] Faculté de Pharmacie,undefined

[8] Université Paris-Sud,undefined

[9] Tour D1,undefined

[10] 2e etage,undefined

[11] EA3544,undefined

来源：

Nature Neuroscience | 2006年 / 9卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment.

引用

页码：729 / 731

页数：2

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