Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

被引：0
|
作者：
Jennifer Landsberg
Judith Kohlmeyer
Marcel Renn
Tobias Bald
Meri Rogava
Mira Cron
Martina Fatho
Volker Lennerz
Thomas Wölfel
Michael Hölzel
Thomas Tüting
机构：
[1] Laboratory of Experimental Dermatology,Department of Dermatology and Allergy
[2] University of Bonn,Third Department of Medicine
[3] D-53105 Bonn,Department of Clinical Chemistry and Clinical Pharmacology
[4] Germany,undefined
[5] Haematology/Oncology/Pneumology,undefined
[6] University Medical Centre of the Johannes Gutenberg University,undefined
[7] D-55101 Mainz,undefined
[8] Germany,undefined
[9] Unit for RNA Biology,undefined
[10] University of Bonn,undefined
[11] D-53105 Bonn,undefined
[12] Germany,undefined
来源：
Nature | 2012年 / 490卷
关键词：
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中图分类号：
学科分类号：
摘要：
A genetically engineered mouse model is used to determine the mechanism of acquired resistance to adoptive therapy with cytotoxic T cells specific for a melanocytic differentiation antigen; tumour necrosis factor (TNF)-α is identified as a crucial factor that causes reversible dedifferentiation of mouse and human melanoma cells.
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页码：412 / 416
页数：4
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