Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

被引：0

作者：

Jennifer Landsberg

Judith Kohlmeyer

Marcel Renn

Tobias Bald

Meri Rogava

Mira Cron

Martina Fatho

Volker Lennerz

Thomas Wölfel

Michael Hölzel

Thomas Tüting

机构：

[1] Laboratory of Experimental Dermatology,Department of Dermatology and Allergy

[2] University of Bonn,Third Department of Medicine

[3] D-53105 Bonn,Department of Clinical Chemistry and Clinical Pharmacology

[4] Germany,undefined

[5] Haematology/Oncology/Pneumology,undefined

[6] University Medical Centre of the Johannes Gutenberg University,undefined

[7] D-55101 Mainz,undefined

[8] Germany,undefined

[9] Unit for RNA Biology,undefined

[10] University of Bonn,undefined

[11] D-53105 Bonn,undefined

[12] Germany,undefined

来源：

Nature | 2012年 / 490卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A genetically engineered mouse model is used to determine the mechanism of acquired resistance to adoptive therapy with cytotoxic T cells specific for a melanocytic differentiation antigen; tumour necrosis factor (TNF)-α is identified as a crucial factor that causes reversible dedifferentiation of mouse and human melanoma cells.

引用

页码：412 / 416

页数：4

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