Serum levels of heat shock protein 27 in patients with acute ischemic stroke

被引：0
|
作者：
Gabriella Gruden
Federica Barutta
Irene Catto
Giovanni Bosco
Maria Giovanna Caprioli
Silvia Pinach
Paolo Fornengo
Paolo Cavallo-Perin
Ottavio Davini
Paolo Cerrato
Graziella Bruno
机构：
[1] University of Turin,Department of Medical Science
[2] Stroke Unit,undefined
[3] San Giovanni Battista Hospital,undefined
[4] Radiology 2 - San Giovanni Battista Hospital,undefined
来源：
Cell Stress and Chaperones | 2013年 / 18卷
关键词：
Acute ischemic stroke; Heat shock protein 27; Serum biomarker; Stress response;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Expression of intracellular heat shock protein 27 (Hsp27) rises in the brain of animal models of cerebral ischemia and stroke. Hsp27 is also released into the circulation and the aim of the present study was to investigated if serum Hsp27 (sHsp27) levels are altered in patients with acute ischemic stroke. sHsp27 was measured in 15 patients with acute ischemic stroke and in 14 control subjects comparable for age, sex, and cardiovascular risk factors. In patients, measurements were performed at admission and 1, 2, and 30 days thereafter. At admission, mean sHsp27 values were threefold higher in patients than in controls. In patients, sHsp27 values dropped after 24 h, rose again at 48 h, and markedly declined at 30 days, indicating the presence of a temporal trend of sHsp27 values following acute ischemic stroke.
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页码：531 / 533
页数：2
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