Liposome production by microfluidics: potential and limiting factors

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作者
Dario Carugo
Elisabetta Bottaro
Joshua Owen
Eleanor Stride
Claudio Nastruzzi
机构
[1] Institute of Biomedical Engineering,Department of Engineering Science
[2] Old Road Campus Research Building,Department of Life Science and Biotechnology
[3] University of Oxford,undefined
[4] Mechatronics and Bioengineering Science research groups,undefined
[5] Faculty of Engineering and the Environment,undefined
[6] University of Southampton,undefined
[7] University of Ferrara,undefined
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This paper provides an analysis of microfluidic techniques for the production of nanoscale lipid-based vesicular systems. In particular we focus on the key issues associated with the microfluidic production of liposomes. These include, but are not limited to, the role of lipid formulation, lipid concentration, residual amount of solvent, production method (including microchannel architecture), and drug loading in determining liposome characteristics. Furthermore, we propose microfluidic architectures for the mass production of liposomes with a view to potential industrial translation of this technology.
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