Effect of histone deacetylase inhibitor sodium butyrate on viability and life span in Drosophila melanogaster

被引：0
|
作者：
Vaiserman A.M. [1 ]
Kolyada A.K. [1 ]
Koshel N.M. [1 ]
Simonenko A.V. [2 ]
Pasyukova E.G. [2 ]
机构：
[1] Cheborarev Institute of Gerontology, AMS of Ukraine, ul. Vyshegorodskaya 67, Kiev
[2] Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akad. Kurchatova 2, Moscow
来源：
Advances in Gerontology | 2013年 / 3卷 / 1期
关键词：
Drosophila melanogaster; hormesis; inhibitors of histone deacetylases; lifespan; sodium butyrate;
D O I：
10.1134/S2079057013010153
中图分类号：
学科分类号：
摘要：
Recently, histone acetylation, which is one of the key epigenetic mechanisms controlling gene expression, has been shown to play an important role in determining lifespan. There are some data that indicate the geroprotective potential of histone deacetylase inhibitors. In the present work, we studied the influence of sodium butyrate, a histone deacetylase inhibitor, on the parameters of viability and lifespan of Drosophila melanogaster. Since sodium butyrate is an effective inducer of epigenetic changes, its application as a life-extending agent (geroprotector) seems rather promising. © 2013 Pleiades Publishing, Ltd.
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页码：30 / 34
页数：4
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