Heteroresistance to Fluconazol in Clinical and Environmental Brazilian Strains of Cryptococcus neoformans/C. gattii Species Complex

被引：3

作者：

Feliciano L.M. ^{[1
]}

Ramos S.D.P. ^{[2
]}

Szeszs M.W. ^{[2
]}

Martins M.A. ^{[2
]}

Bonfietti L.X. ^{[2
]}

Oliveira R.A. ^{[2
]}

Santos D.C.S. ^{[2
]}

Fadul L.H. ^{[2
]}

Silva D.F. ^{[2
]}

Paula C.R. ^{[3
]}

Trilles L. ^{[4
]}

Silva L.E.A. ^{[5
]}

Ferreira-Paim K. ^{[5
]}

Mora D.J. ^{[5
]}

Andrade A.A. ^{[5
]}

Silva P.R. ^{[5
]}

Silva-Vergara M.L. ^{[5
]}

Roberto T.N. ^{[6
]}

Melhem M.S.C. ^{[2
]}

机构：

[1] Graduate Program of the Disease Control Coordination, Secretary of Health, São Paulo

[2] Mycology Department, Instituto Adolfo Lutz, Rio Claro, São Paulo

[3] São Paulo University, São Paulo

[4] Oswaldo Cruz Foundation, Evandro Chagas Clinical Research Institute, Rio de Janeiro

[5] Disciplina de Doenças Infecciosas Parasitárias, Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais

[6] São Paulo Federal University, São Paulo

来源：

Current Fungal Infection Reports | 2017年 / 11卷 / 4期

基金：

巴西圣保罗研究基金会;

关键词：

Antifungal resistance; Cryptococcus gattii; Cryptococcus neoformans; Fluconazole; Heteroresistance;

D O I：

10.1007/s12281-017-0298-1

中图分类号：

学科分类号：

摘要：

Purpose of Study: To review the literature on heteroresistance to fluconazole (FLC) and investigate the level of heteroresistance to FLC (LHF), we analyzed 100 clinical and environmental Brazilian Cryptococcus strains. Recent Findings: Heteroresistance is a phenomenon described as the emergence of resistant subpopulation cells within a single susceptible strain that can tolerate higher concentrations of fluconazole above the minimal inhibitory concentration (MIC) level. Summary: We found lower FLC-MICs (0.12–64 mg/L) than LHF (8–128 mg/L). Highly heteroresistant adapted subpopulations (256 mg/L) was found in minority (9%) strains, but importantly, 33% showed low FLC-MIC (8 mg/L). We concluded for similar LHF in both species, but higher LHF in clinical strains in comparison to environmental ones. Our findings stressed that the LHF is not correlated to species and pretty is strain-dependent and alert about high heteroresistant subpopulations that hardly reverts to the original LHF even upon the removal of drug pressure. © 2017, Springer Science+Business Media, LLC.

引用

页码：190 / 196

页数：6

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