Multiple ligand-specific conformations of the β2-adrenergic receptor

被引：0
|
作者：
Alem W Kahsai
Kunhong Xiao
Sudarshan Rajagopal
Seungkirl Ahn
Arun K Shukla
Jinpeng Sun
Terrence G Oas
Robert J Lefkowitz
机构：
[1] Duke University Medical Center,Department of Medicine
[2] Howard Hughes Medical Institute,Department of Biochemistry
[3] Duke University Medical Center,undefined
[4] Duke University Medical Center,undefined
来源：
Nature Chemical Biology | 2011年 / 7卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A quantitative covalent labeling strategy reveals that multiple ligand-specific conformational states are present in the G protein–coupled β2-adrenergic receptor. Their existence may underlie 'biased agonism', which describes the differential abilities of agonists to activate distinct signaling mechanisms downstream of GPCRs.[graphic not available: see fulltext]
引用
收藏
页码：692 / 700
页数：8
相关论文
共 50 条
  • [41] Activation mechanism of the β2-adrenergic receptor
    Dror, Ron O.
    Arlow, Daniel H.
    Maragakis, Paul
    Mildorf, Thomas J.
    Pan, Albert C.
    Xu, Huafeng
    Borhani, David W.
    Shaw, David E.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (46) : 18684 - 18689
  • [42] α2-adrenergic receptor signalling in hypertension
    Kanagy, NL
    CLINICAL SCIENCE, 2005, 109 (05) : 431 - 437
  • [43] CRYSTAL STRUCTURES OF THE β2-ADRENERGIC RECEPTOR
    Weis, William I.
    Rosenbaum, Daniel M.
    Rasmussen, Soren G. F.
    Choi, Hee-Jung
    Thian, Foon Sun
    Kobilka, Tong Sun
    Yao, Xiao-Jie
    Day, Peter W.
    Parnot, Charles
    Fung, Juan J.
    Ratnala, Venkata R. P.
    Kobilka, Brian K.
    Cherezov, Vadim
    Hanson, Michael A.
    Kuhn, Peter
    Stevens, Raymond C.
    Edwards, Patricia C.
    Schertler, Gebhard F. X.
    Burghammer, Manfred
    Sanishvili, Ruslan
    Fischetti, Robert F.
    Masood, Asna
    Rohrer, Daniel K.
    FROM MOLECULES TO MEDICINES: STRUCTURE OF BIOLOGICAL MACROMOLECULES AND ITS RELEVANCE IN COMBATING NEW DISEASES AND BIOTERRORISM, 2009, : 217 - 230
  • [44] Pharmacogenetics of the β2-adrenergic receptor gene
    Ortega, Victor E.
    Hawkins, Gregory A.
    Peters, Stephen P.
    Bleecker, Eugene R.
    IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2007, 27 (04) : 665 - +
  • [45] Epigenetics Of The β2-Adrenergic Receptor Gene
    Ortega, V. E.
    Liggett, S. B.
    Pascual, R.
    Diallo, A.
    Moore, W. C.
    Meyers, D.
    Bleecker, E. R.
    Hawkins, G. A.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 181
  • [46] Polymorphisms of the β2-adrenergic receptor.
    Liggett, SB
    NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (07): : 536 - 537
  • [47] Modeling the ligand specific μ- and δ-opioid receptor conformations
    Sencanski, Milan
    Ivanovic, Milovan D.
    Vuckovic, Sonja
    Dosen-Micovic, Ljiljana
    JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2011, 76 (09) : 1247 - 1262
  • [48] Ligand-Specific Structural Changes in the Vitamin D Receptor in Solution
    Singarapu, Kiran K.
    Zhu, Jinge
    Tonelli, Marco
    Rao, Hongyu
    Assadi-Porter, Fariba M.
    Westler, William M.
    DeLuca, Hector F.
    Markley, John L.
    BIOCHEMISTRY, 2011, 50 (51) : 11025 - 11033
  • [49] Ligand-specific oligomerization of T-cell receptor molecules
    Ziv Reich
    J. Jay Boniface
    Daniel S. Lyons
    Nina Borochov
    Ellen J. Wachtel
    Mark M. Davis
    Nature, 1997, 387 : 617 - 620
  • [50] Predictive features of ligand-specific signaling through the estrogen receptor
    Nwachukwu, Jerome C.
    Srinivasan, Sathish
    Zheng, Yangfan
    Wang, Song
    Min, Jian
    Dong, Chune
    Liao, Zongquan
    Nowak, Jason
    Wright, Nicholas J.
    Houtman, Rene
    Carlson, Kathryn E.
    Josan, Jatinder S.
    Elemento, Olivier
    Katzenellenbogen, John A.
    Zhou, Hai-Bing
    Nettles, Kendall W.
    MOLECULAR SYSTEMS BIOLOGY, 2016, 12 (04)
12345