Multiple ligand-specific conformations of the β2-adrenergic receptor

被引：0
|
作者：
Alem W Kahsai
Kunhong Xiao
Sudarshan Rajagopal
Seungkirl Ahn
Arun K Shukla
Jinpeng Sun
Terrence G Oas
Robert J Lefkowitz
机构：
[1] Duke University Medical Center,Department of Medicine
[2] Howard Hughes Medical Institute,Department of Biochemistry
[3] Duke University Medical Center,undefined
[4] Duke University Medical Center,undefined
来源：
Nature Chemical Biology | 2011年 / 7卷
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摘要：
A quantitative covalent labeling strategy reveals that multiple ligand-specific conformational states are present in the G protein–coupled β2-adrenergic receptor. Their existence may underlie 'biased agonism', which describes the differential abilities of agonists to activate distinct signaling mechanisms downstream of GPCRs.[graphic not available: see fulltext]
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页码：692 / 700
页数：8
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