Inhibition of the Human Immunodeficiency Virus Type 1 DNA Integration by Modified Oligonucleotides

被引：0
|
作者：
M. D. Pinskaya
P. Brodin
E. A. Romanova
E. M. Volkov
J.-F. Mouscadet
M. B. Gottikh
机构：
[1] Moscow State University,Chemical Faculty
[2] CNRS-UMR 8532,Belozersky Institute of Physico
[3] Institut Gustave Roussy,Chemical Biology
[4] Moscow State University,undefined
来源：
Molecular Biology | 2000年 / 34卷
关键词：
HIV-1; integration; oligonucleotide; quadruplex; triplex-forming oligonucleotide; parallel duplex; phosphorothioate oligonucleotide;
D O I：
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学科分类号：
摘要：
Oligonucleotide inhibitors of the HIV-1 DNA integration identified to date are reviewed. Two basic strategies of blocking the integration are considered: shielding the integrase-binding sites on the viral DNA by triplex-forming oligonucleotides, and directly inhibiting the enzyme with oligonucleotide agents.
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页码：888 / 894
页数：6
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