Efficacy and safety of intravenous imatinib in COVID-19 ARDS: a randomized, double-blind, placebo-controlled clinical trial

被引：0
|
作者：
Leila N. Atmowihardjo
Job R. Schippers
Erik Duijvelaar
Imke H. Bartelink
Pierre M. Bet
Noortje E. L. Swart
Nienke van Rein
Keith Purdy
David Cavalla
Andrew McElroy
Sarah Fritchley
Anton Vonk Noordegraaf
Henrik Endeman
Patricia van Velzen
Matty Koopmans
Harm Jan Bogaard
Leo Heunks
Nicole Juffermans
Marcus J. Schultz
Pieter R. Tuinman
Lieuwe D. J. Bos
Jurjan Aman
机构：
[1] Amsterdam UMC Location University of Amsterdam,Intensive Care
[2] Amsterdam University Medical Centers,Department of Pulmonary Medicine
[3] Location VUmc,Department of Clinical Pharmacology and Pharmacy
[4] Amsterdam UMC Location Vrije Universiteit Amsterdam,Department of Clinical Pharmacology and Pharmacy
[5] Amsterdam UMC Location University of Amsterdam,Department of Clinical Pharmacology and Pharmacy
[6] Leiden UMC,Intensive Care
[7] Exvastat,Intensive Care
[8] Erasmus University Medical Centre,Intensive Care
[9] Dijklander Hospital,Mahidol Oxford Tropical Medicine Research Unit (MORU)
[10] Location Purmerend,Nuffield Department of Medicine
[11] OLVG Hospital Location Oost,Department of Research and Development
[12] Mahidol University,Intensive Care
[13] University of Oxford,Laboratory of Translational Intensive Care
[14] Hamilton Medical AG,undefined
[15] Amsterdam UMC Location Vrije Universiteit Amsterdam,undefined
[16] Erasmus University,undefined
来源：
Critical Care | / 27卷
关键词：
COVID-19; ARDS; Imatinib; Vascular permeability; Endothelial barrier dysfunction; Pulmonary edema;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] The Bexagliflozin Efficacy and Safety Trial (BEST): A Randomized, Double-Blind, Placebo-Controlled, Phase IIII, Clinical Trial
    McMurray, John J. V.
    Freeman, Mason W.
    Massaro, Joe
    Solomon, Scott
    Lock, Paul
    Riddle, Matthew C.
    Halvorsen, Yuan-Di C.
    [J]. DIABETES, 2020, 69
  • [32] Safety and efficacy of favipiravir in COVID-19 patients with pneumonia. A randomized, double-blind, placebo-controlled study (FAVID)
    Juan P. Horcajada
    Rebeca Aldonza
    Mónica Real
    Silvia Castañeda-Espinosa
    Elena Sendra
    Joan Gomez-Junyent
    Inmaculada López-Montesinos
    Silvia Gómez-Zorrilla
    Silvia Briansó
    Montserrat Duran-Taberna
    Andrés Fernández
    Cristina Tarragó
    Teresa Auguet-Quintillá
    [J]. Pneumonia, 16
  • [33] Efficacy and safety of intratonsillar immunotherapy for allergic rhinitis: A randomized, double-blind, placebo-controlled clinical trial
    Zhang, Junyan
    Yang, Xiaobin
    Chen, Guangui
    Hu, Jintao
    He, Ying
    Ma, Jinxiang
    Ma, Zhaoen
    Chen, Huifang
    Huang, Yuyi
    Wu, Qiurong
    Liu, Yongping
    Yu, Lu
    Zhang, Hong
    Lai, He
    Zhang, Jianguo
    Zhai, Jinming
    Huang, Minqi
    Zou, Zehong
    Tao, Ailin
    [J]. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2024, 132 (03) : 346 - 354.e1
  • [34] A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of a Nutritional Supplement (ImmuActiveTM) for COVID-19 Patients
    Majeed, Muhammed
    Nagabhushanam, Kalyanam
    Shah, Kalpesh
    Mundkur, Lakshmi
    [J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2021, 2021
  • [35] Safety and efficacy of favipiravir in COVID-19 patients with pneumonia. A randomized, double-blind, placebo-controlled study (FAVID)
    Horcajada, Juan P.
    Aldonza, Rebeca
    Real, Monica
    Castaneda-Espinosa, Silvia
    Sendra, Elena
    Gomez-Junyent, Joan
    Lopez-Montesinos, Inmaculada
    Gomez-Zorrilla, Silvia
    Brianso, Silvia
    Duran-Taberna, Montserrat
    Fernandez, Andres
    Tarrago, Cristina
    Auguet-Quintilla, Teresa
    [J]. PNEUMONIA, 2024, 16 (01)
  • [36] Efficacy and Safety of Baclofen for Alcohol Dependence: A Randomized, Double-Blind, Placebo-Controlled Trial
    Garbutt, James C.
    Kampov-Polevoy, Alexei B.
    Gallop, Robert
    Kalka-Juhl, Linda
    Flannery, Barbara A.
    [J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2010, 34 (11) : 1849 - 1857
  • [37] Safety and efficacy of tibolone and menopausal transition: a randomized, double-blind placebo-controlled trial
    Maria, Morais-Socorro
    Alvaro, Cavalcanti Maciel
    Rand, Martins
    Paulo, Neto Francisco
    Adriana, Rezende
    George, Azevedo
    Maria, Almeida
    [J]. GYNECOLOGICAL ENDOCRINOLOGY, 2012, 28 (06) : 483 - 487
  • [38] Efficacy of probiotic treatment as post-exposure prophylaxis for COVID-19: A double-blind, Placebo-Controlled Randomized trial
    Wischmeyer, Paul E.
    Tang, Helen
    Ren, Yi
    Bohannon, Lauren
    Jiang, Danting
    Bergens, Matthew
    Ramirez, Zeni E.
    Andermann, Tessa M.
    Messina, Julia A.
    Sung, Julia A.
    Jensen, David
    Jung, Sin-Ho
    Artica, Alexandra
    Britt, Anne
    Bush, Amy
    Johnson, Ernaya
    V. Lew, Meagan
    Winthrop, Hilary
    Pamanes, Claudia
    Racioppi, Alessandro
    Zhao, Aaron T.
    Wan, Zihan
    Surana, Neeraj K.
    Sung, Anthony D.
    [J]. CLINICAL NUTRITION, 2024, 43 (01) : 259 - 267
  • [39] Randomised, Placebo-Controlled, Double-Blind Trial to Assess Efficacy and Safety of ELOM-080 in Outpatients with COVID-19
    Michael Dreher
    Hanna-Teresa Heier
    Andrea Kienle-Gogolok
    Kristina Röschmann-Doose
    Jörg Simon
    Ravi Singhal
    Heidrun Täschner
    Jörn Thomsen
    Joachim Weimer
    Thomas Wittig
    Otto Wonhas
    Manuela Thinesse-Mallwitz
    [J]. Advances in Therapy, 2025, 42 (2) : 1237 - 1250
  • [40] Evaluation of the efficacy and safety of intravenous remdesivir in adult patients with severe COVID-19: study protocol for a phase 3 randomized, double-blind, placebo-controlled, multicentre trial
    Yeming Wang
    Fei Zhou
    Dingyu Zhang
    Jianping Zhao
    Ronghui Du
    Yi Hu
    Zhenshun Cheng
    Ling Gao
    Yang Jin
    Guangwei Luo
    Shouzhi Fu
    Qiaofa Lu
    Guanhua Du
    Ke Wang
    Yang Lu
    Guohui Fan
    Yi Zhang
    Ying Liu
    Shunan Ruan
    Wen Liu
    Thomas Jaki
    Frederick G. Hayden
    Peter W. Horby
    Bin Cao
    Chen Wang
    [J]. Trials, 21
12345