Formation and Properties of Multilayer Films Based on Polyethyleneimine and Bovine Serum Albumin

被引：0
|
作者：
V. I. Kulikouskaya
M. E. Lazouskaya
A. N. Kraskouski
V. E. Agabekov
机构：
[1] Belarus National Academy of Sciences,Institute of Chemistry of New Materials
来源：
Russian Journal of Physical Chemistry A | 2018年 / 92卷
关键词：
multilayer films; quartz crystal microbalance; bovine serum albumin; polyethyleneimine; miramistin; drug release kinetics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
(Polyethyleneimine/bovine serum albumin)n ((PEI/BSA)n) multilayer films (n = 1–10) are produced via the layer-by-later deposition of polyelectrolytes. It is shown that thickness and morphology of the formed coatings can be controlled by varying the solution’s ionic strength during alternating adsorption of the components. (PEI/BSA)10 multilayer systems that contain up to 0.6 mg of antiseptic miramistin per 1 cm2 of film were created. It is established that the kinetics of miramistin release from (PEI/BSA)10 films in phosphate buffers and physiological solutions obey the Korsmeyer–Peppas equation with a high degree of accuracy (R2 > 0.95).
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页码：146 / 152
页数：6
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