Deciphering the role of interleukin-22 in metabolic alterations

被引：0
|
作者：
Robert Sabat
Kerstin Wolk
机构：
[1] University Hospital Charité,Psoriasis Research and Treatment Center
[2] University Hospital Charité,Research Center Immunosciences
[3] University Hospital Charité,Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology
来源：
Cell & Bioscience | / 5卷
关键词：
Obesity; Metabolic alterations; Immunity; Th1-cells; Th17-cells; Th22-cells; ILC3; Diabetes mellitus; Arteriosclerosis; IL-17; TNF-α;
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摘要：
Inflammatory processes and metabolic alterations are supposed to substantially interact. Recently, cumulating reports describe a profound role of interleukin(IL)-22 in this relationship. IL-22 is a particular kind of immune mediator that is produced by certain lymphocyte populations and regulates the function of several tissue cells but not immune cells. So far, IL-22 was known to plays a fundamental role in the elimination of bacterial infections at border surfaces of the body and to protect tissues from damage. This research highlight article arranges the facts regarding the effects of IL-22 in the context of adiposity and metabolic alterations and postulates a new function of the immune system.
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