Fully functional NK cells after unrelated cord blood transplantation

被引：0
|
作者：
V Beziat
S Nguyen
S Lapusan
B Hervier
N Dhedin
D Bories
M Uzunov
A Boudifa
H Trebeden-Negre
F Norol
Z Marjanovic
J-P Marie
J-P Vernant
P Debre
B Rio
V Vieillard
机构：
[1] INSERM U543,Département d'Hématologie et d'Oncologie Médicale
[2] Hôpital Pitié-Salpêtrière,undefined
[3] UPMC,undefined
[4] Université Paris,undefined
[5] Service d'Hématologie Clinique,undefined
[6] Hôpital Pitié-Salpêtrière,undefined
[7] Hôtel Dieu,undefined
[8] Unité d'Hématologie Moléculaire,undefined
[9] Hôpital Henri-Mondor,undefined
[10] Laboratoire d'Immunologie Cellulaire et Tissulaire,undefined
[11] Hôpital Pitié-Salpêtrière,undefined
[12] Laboratoire de Thérapie Cellulaire,undefined
[13] Hôpital Pitié-Salpêtrière,undefined
来源：
Leukemia | 2009年 / 23卷
关键词：
NK cells; cord blood transplantation; GvL effect; cytotoxicity; NK-cell maturation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Promising results of umbilical cord blood transplantation (UCBT) from unrelated donors have been reported in patients with hematologic disorders. These transplants, having potential to trigger beneficial donor-versus-recipient natural killer (NK) cell-mediated alloreaction, we have conducted the first extensive analysis of the phenotypic and functional properties of NK cells after UCBT. NK cells from 25 patients with high-risk hematologic malignancies were compared with cells derived from both healthy adult and CB cells. We found that following UCBT, NK cells display not only some phenotypic features associated with maturity but also unique characteristics that make them fully functional against leukemic blasts. We propose that this full functionality of alloreactive donor-derived NK may drive graft-versus-leukemia reactions after UCBT.
引用
收藏
页码：721 / 728
页数：7
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