The differential effects of IL-1 and TNF-α on proinflammatory cytokine and matrix metalloproteinase expression in human chondrosarcoma cells

被引：0
|
作者：
J. Shi
E. Schmitt-Talbot
D. A. DiMattia
R. G. Dullea
机构：
[1] Pfizer Global Research and Development,Department of Antibacterial, Immunology, and Inflammation
[2] Pfizer Global Research and Development,Department of Genomic and Proteomic Sciences, MS8118D
[3] Auburn University,3031
来源：
Inflammation Research | 2004年 / 53卷
关键词：
IL-1β; TNF-α; MMP; Chondrocyte; Inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective and design:Interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), and matrix metalloproteinases (MMPs) play important roles in the pathogenesis of osteoarthritis (OA). In the present study, using Affymetrix oligonucleotide array technology and real-time quantitative RT-PCR we have investigated the molecular mechanisms underlying the differential effect of IL-1 and TNF-α on gene expression in the human chondrosarcoma cell line, SW1353.
引用
收藏
页码：377 / 389
页数：12
相关论文
共 50 条
  • [41] Polymorphism of IL-1β, IL-1Ra, TNF-α cytokine genes in Korean patients with glomerulonephritis
    Ihm, Chun-Gyoo
    Lee, T. W.
    Lee, S. H.
    Jeong, K. H.
    Park, M. N.
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2007, 22 : 294 - 294
  • [42] The effects of IL-10 on proinflammatory cytokine expression (IL-1β and IL-8) in hyaline membrane disease (HMD)
    Kwong, KYC
    Jones, CA
    Cayabyab, R
    Lecart, C
    Khuu, N
    Rhandhawa, I
    Hanley, JM
    Ramanathan, R
    deLemos, RA
    Minoo, P
    CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1998, 88 (01): : 105 - 113
  • [43] TNf-α and IL-1β stimulate MCP-1 secretion by human PDL cells.
    Deschner, J
    Müller, M
    Budzynski, M
    Beuth, J
    Ko, HL
    Noack, MJ
    JOURNAL OF DENTAL RESEARCH, 2002, 81 : B235 - B235
  • [44] TNF-α but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis
    Mariani, E
    Tarozzi, A
    Meneghetti, A
    Cattini, L
    Facchini, A
    INTERNATIONAL JOURNAL OF ONCOLOGY, 1998, 13 (02) : 349 - 353
  • [45] Expression of proinflammatory cytokines IL-1β, IL-6 and TNFα in the retained placenta of mares
    Jaworska, J.
    Janowski, T.
    THERIOGENOLOGY, 2019, 126 : 1 - 7
  • [46] Expression of proinflammatory cytokines IL-1β, IL-6 and TNFα in the retained placenta of mares
    Jaworska, J.
    Janowski, T.
    REPRODUCTION IN DOMESTIC ANIMALS, 2018, 53 : 148 - 148
  • [47] Expression and Function of TNF and IL-1 Receptors on Human Regulatory T Cells
    Mercer, Frances
    Kozhaya, Lina
    Unutmaz, Derya
    PLOS ONE, 2010, 5 (01):
  • [48] Effects of aging on serum and brain levels of IL-1β and TNF-α.
    Vella, L
    Hamilton, JS
    Horwitz, BA
    FASEB JOURNAL, 2002, 16 (04): : A395 - A396
  • [49] Differential effects of NF-κB and p38 MAPK inhibitors and combinations thereof on TNF-α- and IL-1β-induced proinflammatory status of endothelial cells in vitro
    Kuldo, JM
    Westra, J
    Asgeirsdóttir, SA
    Kok, RJ
    Oosterhuis, K
    Rots, MG
    Schouten, JP
    Limburg, PC
    Molema, G
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2005, 289 (05): : C1229 - C1239
  • [50] Effects of TNF-α and IL-1β on iron metabolism by A549 cells and influence on cytotoxicity
    Smirnov, IM
    Bailey, K
    Flowers, CH
    Garrigues, NW
    Wesselius, LJ
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1999, 277 (02) : L257 - L263
12345